Specifically, in this experiment set, known experiment labels are:
This report contains all the functional information that was requested by the options when functional_Hunter.R was executed. The functional categories can be:
All the functional categories are computed with ClusterProfiler and GO categories are computed also with TopGo.
Some sections will not show if there are not sinficative results. Each category is analysed using Over representation analysis (ORA) and Gene Set Analysis (GSEA). The ORA method takes a group of significative DEGs (only DEGs, upregulated DEGs or downregulated DEGs) and performs a hypergeometric test for each term of the selected functional category. In the case of the GSEA method, all the genes are sorted by their fold-change and the algorithm scan which genes with similar fold-change shares a term of the selected functional category.
Statistics about input results obtained from DEGenes Expression Hunter are:
| Gene_tag | Genes |
|---|---|
| NOT_DEG | 15317 |
| POSSIBLE_DEG | 351 |
| PREVALENT_DEG | 698 |
Table of signifcant genes. Variables taken into account are being shown into table (except gene symbols/ID). Top of positive (19 items) and negative (16 items) are being shown in two different tables
| rownames | input_IDs | logFC_DESeq2 | logFC_edgeR | mean_logFCs | SYMBOL |
|---|---|---|---|---|---|
| ENSG00000248752 | ENSG00000248752 | 4.99362884319258 | 5.92210361914924 | 5.45786623117091 | NA |
| ENSG00000239503 | ENSG00000239503 | 5.0268612328416 | 4.78207459342231 | 4.90446791313196 | NA |
| ENSG00000170522 | ENSG00000170522 | 5.0468950687396 | 5.97377576624718 | 5.51033541749339 | ELOVL6 |
| ENSG00000106070 | ENSG00000106070 | 5.05115795885436 | 5.97583685217659 | 5.51349740551548 | GRB10 |
| ENSG00000223525 | ENSG00000223525 | 5.05318450244465 | 5.97628186669892 | 5.51473318457179 | NA |
| ENSG00000279996 | ENSG00000279996 | 5.08682391552295 | 4.83412666675982 | 4.96047529114139 | NA |
| ENSG00000223646 | ENSG00000223646 | 5.181541803924 | 6.11128759178856 | 5.64641469785628 | LOC101928012 |
| ENSG00000164120 | ENSG00000164120 | 5.21397804579226 | 4.96276648304253 | 5.0883722644174 | HPGD |
| ENSG00000166535 | ENSG00000166535 | 5.71892268680558 | 5.47079996065518 | 5.59486132373038 | A2ML1 |
| ENSG00000163534 | ENSG00000163534 | 5.76328490012225 | 5.71115295155166 | 5.73721892583695 | FCRL1 |
| ENSG00000248837 | ENSG00000248837 | 5.96936352182643 | 6.88447490987186 | 6.42691921584915 | LOC105374524 |
| ENSG00000249948 | ENSG00000249948 | 6.06699164935877 | 6.98448743939958 | 6.52573954437917 | GBA3 |
| ENSG00000171517 | ENSG00000171517 | 6.28483532162719 | 7.19780420514928 | 6.74131976338823 | LPAR3 |
| ENSG00000132704 | ENSG00000132704 | 7.02521246130768 | 7.9331425872725 | 7.47917752429009 | FCRL2 |
| ENSG00000073754 | ENSG00000073754 | 7.61383873767194 | 7.42080959780015 | 7.51732416773605 | CD5L |
| ENSG00000277913 | ENSG00000277913 | 4.81277226859045 | 5.7488517784667 | 5.28081202352857 | NA |
| ENSG00000224081 | ENSG00000224081 | 4.83203592061477 | 5.75843026039269 | 5.29523309050373 | NA |
| ENSG00000271553 | ENSG00000271553 | 4.93748303016735 | 5.86788360336815 | 5.40268331676775 | NA |
| ENSG00000233186 | ENSG00000233186 | 4.95334876466837 | 5.87573792710228 | 5.41454334588533 | KLF4P1 |
| rownames | input_IDs | logFC_DESeq2 | logFC_edgeR | mean_logFCs | SYMBOL |
|---|---|---|---|---|---|
| ENSG00000248752 | ENSG00000248752 | 4.99362884319258 | 5.92210361914924 | 5.45786623117091 | NA |
| ENSG00000239503 | ENSG00000239503 | 5.0268612328416 | 4.78207459342231 | 4.90446791313196 | NA |
| ENSG00000170522 | ENSG00000170522 | 5.0468950687396 | 5.97377576624718 | 5.51033541749339 | ELOVL6 |
| ENSG00000106070 | ENSG00000106070 | 5.05115795885436 | 5.97583685217659 | 5.51349740551548 | GRB10 |
| ENSG00000223525 | ENSG00000223525 | 5.05318450244465 | 5.97628186669892 | 5.51473318457179 | NA |
| ENSG00000279996 | ENSG00000279996 | 5.08682391552295 | 4.83412666675982 | 4.96047529114139 | NA |
| ENSG00000223646 | ENSG00000223646 | 5.181541803924 | 6.11128759178856 | 5.64641469785628 | LOC101928012 |
| ENSG00000164120 | ENSG00000164120 | 5.21397804579226 | 4.96276648304253 | 5.0883722644174 | HPGD |
| ENSG00000166535 | ENSG00000166535 | 5.71892268680558 | 5.47079996065518 | 5.59486132373038 | A2ML1 |
| ENSG00000163534 | ENSG00000163534 | 5.76328490012225 | 5.71115295155166 | 5.73721892583695 | FCRL1 |
| ENSG00000248837 | ENSG00000248837 | 5.96936352182643 | 6.88447490987186 | 6.42691921584915 | LOC105374524 |
| ENSG00000249948 | ENSG00000249948 | 6.06699164935877 | 6.98448743939958 | 6.52573954437917 | GBA3 |
| ENSG00000171517 | ENSG00000171517 | 6.28483532162719 | 7.19780420514928 | 6.74131976338823 | LPAR3 |
| ENSG00000132704 | ENSG00000132704 | 7.02521246130768 | 7.9331425872725 | 7.47917752429009 | FCRL2 |
| ENSG00000073754 | ENSG00000073754 | 7.61383873767194 | 7.42080959780015 | 7.51732416773605 | CD5L |
| ENSG00000277913 | ENSG00000277913 | 4.81277226859045 | 5.7488517784667 | 5.28081202352857 | NA |
| ENSG00000224081 | ENSG00000224081 | 4.83203592061477 | 5.75843026039269 | 5.29523309050373 | NA |
| ENSG00000271553 | ENSG00000271553 | 4.93748303016735 | 5.86788360336815 | 5.40268331676775 | NA |
| ENSG00000233186 | ENSG00000233186 | 4.95334876466837 | 5.87573792710228 | 5.41454334588533 | KLF4P1 |
The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.
BarplotThe most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.
The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.
Distributions of Log2FC
This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.
Gene-Concept Network
The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.
The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.
Significant genes (x-axis) and the functional categories in which they appear.
Upsetplot
Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).
The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.
BarplotThe most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.
The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.
Distributions of Log2FC
This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.
Gene-Concept Network
The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.
The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.
Significant genes (x-axis) and the functional categories in which they appear.
Upsetplot
Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).
The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.
BarplotThe most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.
The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.
Distributions of Log2FC
This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.
Gene-Concept Network
The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.
The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.
Significant genes (x-axis) and the functional categories in which they appear.
Upsetplot
Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).
The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.
BarplotThe most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.
The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.
Distributions of Log2FC
This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.
Gene-Concept Network
The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.
The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.
Significant genes (x-axis) and the functional categories in which they appear.
Upsetplot
Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).
| GO.ID | Term | positive.PC.1 | negative.PC.1 | positive.PC.2 | negative.PC.2 |
|---|---|---|---|---|---|
| GO:0002181 | cytoplasmic translation | 7.28e-19 | NA | NA | NA |
| GO:0002399 | MHC class II protein complex assembly | 2.34e-12 | NA | NA | NA |
| GO:0002503 | peptide antigen assembly with MHC class ... | 2.34e-12 | NA | NA | NA |
| GO:0006412 | translation | 2.79e-11 | NA | NA | NA |
| GO:0032543 | mitochondrial translation | 5.54e-08 | NA | NA | NA |
| GO:0061844 | antimicrobial humoral immune response me... | 1.44e-06 | NA | NA | NA |
| GO:0019730 | antimicrobial humoral response | 1.12e-05 | NA | NA | NA |
| GO:0140053 | mitochondrial gene expression | 2.05e-05 | NA | NA | NA |
| GO:0001906 | cell killing | 3.00e-05 | NA | NA | NA |
| GO:0002504 | antigen processing and presentation of p... | 6.74e-05 | NA | NA | NA |
| GO:0002495 | antigen processing and presentation of p... | 1.61e-04 | NA | NA | NA |
| GO:0006119 | oxidative phosphorylation | 1.80e-04 | NA | NA | 1.77e-02 |
| GO:0043069 | negative regulation of programmed cell d... | 2.08e-04 | NA | NA | NA |
| GO:0006959 | humoral immune response | 2.08e-04 | NA | NA | NA |
| GO:0002396 | MHC protein complex assembly | 2.08e-04 | NA | NA | NA |
| GO:0002501 | peptide antigen assembly with MHC protei... | 2.08e-04 | NA | NA | NA |
| GO:0043066 | negative regulation of apoptotic process | 4.65e-04 | NA | NA | NA |
| GO:0048002 | antigen processing and presentation of p... | 4.90e-04 | NA | NA | NA |
| GO:0045333 | cellular respiration | 5.82e-04 | NA | NA | 1.46e-03 |
| GO:0002227 | innate immune response in mucosa | 6.69e-04 | NA | NA | NA |
| GO:1990748 | cellular detoxification | 1.06e-03 | NA | NA | NA |
| GO:0019538 | protein metabolic process | 1.06e-03 | NA | NA | NA |
| GO:0097237 | cellular response to toxic substance | 1.06e-03 | NA | NA | NA |
| GO:0019886 | antigen processing and presentation of e... | 1.09e-03 | NA | NA | NA |
| GO:0002478 | antigen processing and presentation of e... | 1.13e-03 | NA | NA | NA |
| GO:0032353 | negative regulation of hormone biosynthe... | 1.79e-03 | NA | NA | NA |
| GO:0002437 | inflammatory response to antigenic stimu... | 1.79e-03 | NA | NA | NA |
| GO:0097250 | mitochondrial respirasome assembly | 1.85e-03 | NA | NA | 1.32e-02 |
| GO:0030162 | regulation of proteolysis | 2.11e-03 | NA | NA | NA |
| GO:0019882 | antigen processing and presentation | 2.11e-03 | NA | NA | NA |
| GO:0098869 | cellular oxidant detoxification | 2.93e-03 | NA | NA | NA |
| GO:2001234 | negative regulation of apoptotic signali... | 2.99e-03 | NA | NA | NA |
| GO:0051246 | regulation of protein metabolic process | 3.80e-03 | NA | NA | NA |
| GO:0061644 | protein localization to CENP-A containin... | 3.80e-03 | NA | NA | NA |
| GO:0097707 | ferroptosis | 3.80e-03 | NA | NA | NA |
| GO:0019884 | antigen processing and presentation of e... | 3.80e-03 | NA | NA | NA |
| GO:0033108 | mitochondrial respiratory chain complex ... | 4.02e-03 | NA | NA | 7.20e-03 |
| GO:0009060 | aerobic respiration | 4.02e-03 | NA | NA | 1.40e-03 |
| GO:0006508 | proteolysis | 4.02e-03 | NA | NA | NA |
| GO:2001233 | regulation of apoptotic signaling pathwa... | 4.11e-03 | NA | NA | NA |
| GO:0097529 | myeloid leukocyte migration | 4.11e-03 | NA | NA | NA |
| GO:0036261 | 7-methylguanosine cap hypermethylation | 4.40e-03 | NA | NA | NA |
| GO:0002536 | respiratory burst involved in inflammato... | 4.63e-03 | NA | NA | NA |
| GO:0110076 | negative regulation of ferroptosis | 4.94e-03 | NA | NA | NA |
| GO:2001242 | regulation of intrinsic apoptotic signal... | 5.15e-03 | NA | NA | NA |
| GO:2001243 | negative regulation of intrinsic apoptot... | 5.71e-03 | NA | NA | NA |
| GO:0022904 | respiratory electron transport chain | 7.52e-03 | NA | NA | NA |
| GO:0098754 | detoxification | 7.52e-03 | NA | NA | NA |
| GO:0033615 | mitochondrial proton-transporting ATP sy... | 8.17e-03 | NA | NA | NA |
| GO:0043461 | proton-transporting ATP synthase complex... | 8.17e-03 | NA | NA | NA |
| GO:0006694 | steroid biosynthetic process | 8.79e-03 | NA | NA | NA |
| GO:0110075 | regulation of ferroptosis | 8.80e-03 | NA | NA | NA |
| GO:0001731 | formation of translation preinitiation c... | 9.14e-03 | NA | NA | NA |
| GO:1902624 | positive regulation of neutrophil migrat... | 9.14e-03 | NA | NA | NA |
| GO:0007056 | spindle assembly involved in female meio... | 9.65e-03 | NA | NA | NA |
| GO:0051604 | protein maturation | 1.12e-02 | NA | NA | NA |
| GO:0030163 | protein catabolic process | 1.13e-02 | NA | NA | NA |
| GO:0001909 | leukocyte mediated cytotoxicity | 1.21e-02 | NA | NA | NA |
| GO:0031640 | killing of cells of another organism | 1.21e-02 | NA | NA | NA |
| GO:0141061 | disruption of cell in another organism | 1.21e-02 | NA | NA | NA |
| GO:0009636 | response to toxic substance | 1.24e-02 | NA | NA | NA |
| GO:0002548 | monocyte chemotaxis | 1.29e-02 | NA | NA | NA |
| GO:0051603 | proteolysis involved in protein cataboli... | 1.30e-02 | NA | NA | NA |
| GO:0019731 | antibacterial humoral response | 1.30e-02 | NA | NA | NA |
| GO:0016126 | sterol biosynthetic process | 1.30e-02 | NA | NA | NA |
| GO:0022900 | electron transport chain | 1.33e-02 | NA | NA | NA |
| GO:0006121 | mitochondrial electron transport, succin... | 1.34e-02 | NA | NA | NA |
| GO:1902622 | regulation of neutrophil migration | 1.39e-02 | NA | NA | NA |
| GO:0042773 | ATP synthesis coupled electron transport | 1.48e-02 | NA | NA | NA |
| GO:0042775 | mitochondrial ATP synthesis coupled elec... | 1.48e-02 | NA | NA | NA |
| GO:1902253 | regulation of intrinsic apoptotic signal... | 1.66e-02 | NA | NA | NA |
| GO:0048227 | plasma membrane to endosome transport | 1.66e-02 | NA | NA | NA |
| GO:0042110 | T cell activation | 2.04e-02 | NA | NA | NA |
| GO:0006839 | mitochondrial transport | 2.06e-02 | NA | NA | 1.92e-02 |
| GO:0141060 | disruption of anatomical structure in an... | 2.09e-02 | NA | NA | NA |
| GO:1901029 | negative regulation of mitochondrial out... | 2.16e-02 | NA | NA | NA |
| GO:1901617 | organic hydroxy compound biosynthetic pr... | 2.29e-02 | NA | NA | NA |
| GO:0006413 | translational initiation | 2.32e-02 | NA | NA | NA |
| GO:0006457 | protein folding | 2.34e-02 | NA | NA | NA |
| GO:0097190 | apoptotic signaling pathway | 2.47e-02 | NA | NA | NA |
| GO:0002687 | positive regulation of leukocyte migrati... | 2.48e-02 | NA | NA | NA |
| GO:1990544 | mitochondrial ATP transmembrane transpor... | 2.62e-02 | NA | NA | NA |
| GO:0002861 | regulation of inflammatory response to a... | 2.62e-02 | NA | NA | NA |
| GO:0044419 | biological process involved in interspec... | 2.94e-02 | NA | NA | NA |
| GO:0050729 | positive regulation of inflammatory resp... | 3.04e-02 | NA | NA | NA |
| GO:0006879 | intracellular iron ion homeostasis | 3.06e-02 | NA | NA | NA |
| GO:0002835 | negative regulation of response to tumor... | 3.16e-02 | NA | NA | NA |
| GO:0002838 | negative regulation of immune response t... | 3.16e-02 | NA | NA | NA |
| GO:1901137 | carbohydrate derivative biosynthetic pro... | 3.23e-02 | NA | NA | 1.12e-03 |
| GO:0052548 | regulation of endopeptidase activity | 3.24e-02 | NA | NA | NA |
| GO:1902523 | positive regulation of protein K63-linke... | 3.33e-02 | NA | NA | NA |
| GO:0097530 | granulocyte migration | 3.47e-02 | NA | NA | NA |
| GO:0002709 | regulation of T cell mediated immunity | 3.71e-02 | NA | NA | NA |
| GO:0061077 | chaperone-mediated protein folding | 3.81e-02 | NA | NA | NA |
| GO:0034109 | homotypic cell-cell adhesion | 3.81e-02 | NA | NA | NA |
| GO:1902956 | regulation of mitochondrial electron tra... | 3.81e-02 | NA | NA | NA |
| GO:0019646 | aerobic electron transport chain | 3.81e-02 | NA | NA | NA |
| GO:0007005 | mitochondrion organization | 3.81e-02 | NA | NA | NA |
| GO:0006754 | ATP biosynthetic process | 3.81e-02 | NA | NA | 2.52e-02 |
| GO:0061450 | trophoblast cell migration | 3.81e-02 | NA | NA | NA |
| GO:1901163 | regulation of trophoblast cell migration | 3.81e-02 | NA | NA | NA |
| GO:1903715 | regulation of aerobic respiration | 3.82e-02 | NA | NA | NA |
| GO:0043207 | response to external biotic stimulus | 3.82e-02 | NA | NA | NA |
| GO:0051707 | response to other organism | 3.82e-02 | NA | NA | NA |
| GO:0015980 | energy derivation by oxidation of organi... | 3.85e-02 | NA | NA | 2.16e-02 |
| GO:1902235 | regulation of endoplasmic reticulum stre... | 3.88e-02 | NA | NA | NA |
| GO:0043457 | regulation of cellular respiration | 3.94e-02 | NA | NA | NA |
| GO:0002424 | T cell mediated immune response to tumor... | 3.99e-02 | NA | NA | NA |
| GO:0007006 | mitochondrial membrane organization | 4.01e-02 | NA | NA | NA |
| GO:0052547 | regulation of peptidase activity | 4.02e-02 | NA | NA | NA |
| GO:1903003 | positive regulation of protein deubiquit... | 4.04e-02 | NA | NA | NA |
| GO:0032733 | positive regulation of interleukin-10 pr... | 4.25e-02 | NA | NA | NA |
| GO:0050900 | leukocyte migration | 4.25e-02 | NA | NA | NA |
| GO:0002685 | regulation of leukocyte migration | 4.25e-02 | NA | NA | NA |
| GO:0007159 | leukocyte cell-cell adhesion | 4.37e-02 | NA | NA | NA |
| GO:0030003 | intracellular monoatomic cation homeosta... | 4.43e-02 | NA | NA | NA |
| GO:0070431 | nucleotide-binding oligomerization domai... | 4.47e-02 | NA | NA | NA |
| GO:1901135 | carbohydrate derivative metabolic proces... | 4.50e-02 | NA | NA | 5.78e-03 |
| GO:0015986 | proton motive force-driven ATP synthesis | 4.50e-02 | NA | NA | 3.53e-02 |
| GO:0060264 | regulation of respiratory burst involved... | 4.52e-02 | NA | NA | NA |
| GO:0089718 | amino acid import across plasma membrane | 4.84e-02 | NA | NA | NA |
| GO:0072677 | eosinophil migration | 4.86e-02 | NA | NA | NA |
| GO:0001913 | T cell mediated cytotoxicity | 4.86e-02 | NA | NA | NA |
| GO:0032613 | interleukin-10 production | 4.86e-02 | NA | NA | NA |
| GO:0032653 | regulation of interleukin-10 production | 4.86e-02 | NA | NA | NA |
| GO:0006325 | chromatin organization | NA | 7.31e-11 | 4.10e-04 | NA |
| GO:0006338 | chromatin remodeling | NA | 5.59e-09 | 2.11e-03 | NA |
| GO:0051056 | regulation of small GTPase mediated sign... | NA | 6.34e-07 | NA | NA |
| GO:0019219 | regulation of nucleobase-containing comp... | NA | 4.60e-05 | 5.13e-03 | NA |
| GO:0051252 | regulation of RNA metabolic process | NA | 4.60e-05 | 5.23e-04 | NA |
| GO:0034983 | peptidyl-lysine deacetylation | NA | 4.82e-05 | NA | NA |
| GO:0006355 | regulation of DNA-templated transcriptio... | NA | 4.98e-05 | 1.13e-02 | NA |
| GO:2001141 | regulation of RNA biosynthetic process | NA | 4.98e-05 | 7.24e-03 | NA |
| GO:0051254 | positive regulation of RNA metabolic pro... | NA | 8.30e-05 | 1.30e-02 | NA |
| GO:0090304 | nucleic acid metabolic process | NA | 9.15e-05 | NA | NA |
| GO:0006351 | DNA-templated transcription | NA | 1.80e-04 | 2.41e-02 | NA |
| GO:0016043 | cellular component organization | NA | 1.80e-04 | 1.59e-06 | NA |
| GO:0045935 | positive regulation of nucleobase-contai... | NA | 1.80e-04 | NA | NA |
| GO:0045893 | positive regulation of DNA-templated tra... | NA | 2.41e-04 | 3.68e-02 | NA |
| GO:1902680 | positive regulation of RNA biosynthetic ... | NA | 2.41e-04 | 3.92e-02 | NA |
| GO:0006366 | transcription by RNA polymerase II | NA | 4.25e-04 | 1.45e-02 | NA |
| GO:0006357 | regulation of transcription by RNA polym... | NA | 4.46e-04 | 1.24e-02 | NA |
| GO:0016070 | RNA metabolic process | NA | 8.98e-04 | NA | NA |
| GO:0007010 | cytoskeleton organization | NA | 9.37e-04 | NA | NA |
| GO:0006974 | DNA damage response | NA | 2.09e-03 | NA | NA |
| GO:0009190 | cyclic nucleotide biosynthetic process | NA | 2.44e-03 | NA | NA |
| GO:0071840 | cellular component organization or bioge... | NA | 2.44e-03 | 3.03e-04 | NA |
| GO:0141187 | nucleic acid biosynthetic process | NA | 3.24e-03 | NA | NA |
| GO:0006281 | DNA repair | NA | 4.15e-03 | NA | NA |
| GO:0006139 | nucleobase-containing compound metabolic... | NA | 4.21e-03 | NA | NA |
| GO:0032774 | RNA biosynthetic process | NA | 4.33e-03 | NA | NA |
| GO:0048386 | positive regulation of retinoic acid rec... | NA | 5.74e-03 | NA | NA |
| GO:0006171 | cAMP biosynthetic process | NA | 5.84e-03 | NA | NA |
| GO:0018393 | internal peptidyl-lysine acetylation | NA | 5.97e-03 | NA | NA |
| GO:0007264 | small GTPase-mediated signal transductio... | NA | 6.86e-03 | NA | NA |
| GO:1902679 | negative regulation of RNA biosynthetic ... | NA | 1.07e-02 | NA | NA |
| GO:0045892 | negative regulation of DNA-templated tra... | NA | 1.19e-02 | NA | NA |
| GO:0106015 | negative regulation of inflammatory resp... | NA | 1.40e-02 | NA | NA |
| GO:0000122 | negative regulation of transcription by ... | NA | 1.45e-02 | NA | NA |
| GO:0045934 | negative regulation of nucleobase-contai... | NA | 1.56e-02 | NA | NA |
| GO:0034654 | nucleobase-containing compound biosynthe... | NA | 1.85e-02 | NA | NA |
| GO:0001957 | intramembranous ossification | NA | 1.89e-02 | NA | NA |
| GO:0036072 | direct ossification | NA | 1.89e-02 | NA | NA |
| GO:0050794 | regulation of cellular process | NA | 1.97e-02 | 1.18e-05 | NA |
| GO:1904781 | positive regulation of protein localizat... | NA | 2.00e-02 | NA | NA |
| GO:0050770 | regulation of axonogenesis | NA | 2.22e-02 | NA | NA |
| GO:0000076 | DNA replication checkpoint signaling | NA | 2.28e-02 | NA | NA |
| GO:0000226 | microtubule cytoskeleton organization | NA | 2.80e-02 | NA | NA |
| GO:0045944 | positive regulation of transcription by ... | NA | 3.18e-02 | 9.53e-03 | NA |
| GO:0007507 | heart development | NA | 3.24e-02 | NA | NA |
| GO:0090521 | podocyte cell migration | NA | 3.32e-02 | NA | NA |
| GO:0016310 | phosphorylation | NA | 3.32e-02 | NA | NA |
| GO:0098534 | centriole assembly | NA | 3.63e-02 | NA | NA |
| GO:0048856 | anatomical structure development | NA | 3.99e-02 | NA | NA |
| GO:1903939 | regulation of TORC2 signaling | NA | 4.26e-02 | NA | NA |
| GO:0051253 | negative regulation of RNA metabolic pro... | NA | 4.31e-02 | NA | NA |
| GO:0048731 | system development | NA | 4.34e-02 | 2.24e-02 | NA |
| GO:0046777 | protein autophosphorylation | NA | 4.34e-02 | NA | NA |
| GO:0072017 | distal tubule development | NA | 4.34e-02 | NA | NA |
| GO:0007275 | multicellular organism development | NA | 4.56e-02 | 2.10e-02 | NA |
| GO:0010468 | regulation of gene expression | NA | 4.68e-02 | 2.22e-03 | NA |
| GO:0065007 | biological regulation | NA | NA | 4.49e-06 | NA |
| GO:0050789 | regulation of biological process | NA | NA | 9.85e-06 | NA |
| GO:0016192 | vesicle-mediated transport | NA | NA | 1.84e-05 | NA |
| GO:0051649 | establishment of localization in cell | NA | NA | 4.77e-05 | NA |
| GO:0051641 | cellular localization | NA | NA | 6.45e-05 | NA |
| GO:0007033 | vacuole organization | NA | NA | 1.69e-04 | NA |
| GO:0070925 | organelle assembly | NA | NA | 3.29e-04 | NA |
| GO:0033036 | macromolecule localization | NA | NA | 5.23e-04 | NA |
| GO:0051128 | regulation of cellular component organiz... | NA | NA | 5.23e-04 | NA |
| GO:0048523 | negative regulation of cellular process | NA | NA | 5.23e-04 | NA |
| GO:0044088 | regulation of vacuole organization | NA | NA | 5.56e-04 | NA |
| GO:0070727 | cellular macromolecule localization | NA | NA | 6.24e-04 | NA |
| GO:0046907 | intracellular transport | NA | NA | 8.56e-04 | NA |
| GO:0015031 | protein transport | NA | NA | 8.56e-04 | NA |
| GO:0008104 | protein localization | NA | NA | 8.82e-04 | NA |
| GO:0051130 | positive regulation of cellular componen... | NA | NA | 9.34e-04 | NA |
| GO:0031323 | regulation of cellular metabolic process | NA | NA | 1.06e-03 | NA |
| GO:0010743 | regulation of macrophage derived foam ce... | NA | NA | 1.25e-03 | NA |
| GO:0019222 | regulation of metabolic process | NA | NA | 1.30e-03 | NA |
| GO:0016050 | vesicle organization | NA | NA | 1.46e-03 | NA |
| GO:0006996 | organelle organization | NA | NA | 2.05e-03 | NA |
| GO:0048519 | negative regulation of biological proces... | NA | NA | 2.11e-03 | NA |
| GO:0060255 | regulation of macromolecule metabolic pr... | NA | NA | 2.24e-03 | NA |
| GO:0120036 | plasma membrane bounded cell projection ... | NA | NA | 3.34e-03 | NA |
| GO:2000785 | regulation of autophagosome assembly | NA | NA | 3.34e-03 | NA |
| GO:0060271 | cilium assembly | NA | NA | 4.00e-03 | NA |
| GO:0010556 | regulation of macromolecule biosynthetic... | NA | NA | 4.06e-03 | NA |
| GO:0046856 | phosphatidylinositol dephosphorylation | NA | NA | 4.06e-03 | NA |
| GO:0045184 | establishment of protein localization | NA | NA | 4.06e-03 | NA |
| GO:0030030 | cell projection organization | NA | NA | 4.31e-03 | NA |
| GO:0071705 | nitrogen compound transport | NA | NA | 4.40e-03 | NA |
| GO:0009889 | regulation of biosynthetic process | NA | NA | 5.13e-03 | NA |
| GO:0051129 | negative regulation of cellular componen... | NA | NA | 5.13e-03 | NA |
| GO:0046348 | amino sugar catabolic process | NA | NA | 5.72e-03 | NA |
| GO:0016197 | endosomal transport | NA | NA | 5.72e-03 | NA |
| GO:0000910 | cytokinesis | NA | NA | 5.72e-03 | NA |
| GO:0007034 | vacuolar transport | NA | NA | 6.02e-03 | NA |
| GO:0031326 | regulation of cellular biosynthetic proc... | NA | NA | 6.31e-03 | NA |
| GO:0022607 | cellular component assembly | NA | NA | 6.52e-03 | NA |
| GO:0044248 | cellular catabolic process | NA | NA | 6.78e-03 | NA |
| GO:0010256 | endomembrane system organization | NA | NA | 6.78e-03 | NA |
| GO:0120031 | plasma membrane bounded cell projection ... | NA | NA | 7.24e-03 | NA |
| GO:0006886 | intracellular protein transport | NA | NA | 7.24e-03 | NA |
| GO:0080090 | regulation of primary metabolic process | NA | NA | 1.07e-02 | NA |
| GO:0044782 | cilium organization | NA | NA | 1.07e-02 | NA |
| GO:1902115 | regulation of organelle assembly | NA | NA | 1.10e-02 | NA |
| GO:0030031 | cell projection assembly | NA | NA | 1.17e-02 | NA |
| GO:0033043 | regulation of organelle organization | NA | NA | 1.39e-02 | NA |
| GO:1905037 | autophagosome organization | NA | NA | 1.45e-02 | NA |
| GO:0048609 | multicellular organismal reproductive pr... | NA | NA | 1.46e-02 | NA |
| GO:0007626 | locomotory behavior | NA | NA | 1.46e-02 | NA |
| GO:0006914 | autophagy | NA | NA | 1.46e-02 | NA |
| GO:0061919 | process utilizing autophagic mechanism | NA | NA | 1.46e-02 | NA |
| GO:0099003 | vesicle-mediated transport in synapse | NA | NA | 1.46e-02 | NA |
| GO:0007030 | Golgi organization | NA | NA | 1.51e-02 | NA |
| GO:0061512 | protein localization to cilium | NA | NA | 1.53e-02 | NA |
| GO:0061640 | cytoskeleton-dependent cytokinesis | NA | NA | 1.68e-02 | NA |
| GO:0031324 | negative regulation of cellular metaboli... | NA | NA | 1.70e-02 | NA |
| GO:0007041 | lysosomal transport | NA | NA | 1.70e-02 | NA |
| GO:0010638 | positive regulation of organelle organiz... | NA | NA | 1.80e-02 | NA |
| GO:0014059 | regulation of dopamine secretion | NA | NA | 1.83e-02 | NA |
| GO:0010629 | negative regulation of gene expression | NA | NA | 1.87e-02 | NA |
| GO:0009892 | negative regulation of metabolic process | NA | NA | 1.87e-02 | NA |
| GO:0007040 | lysosome organization | NA | NA | 1.87e-02 | NA |
| GO:0080171 | lytic vacuole organization | NA | NA | 1.87e-02 | NA |
| GO:0007254 | JNK cascade | NA | NA | 1.87e-02 | NA |
| GO:0048193 | Golgi vesicle transport | NA | NA | 2.00e-02 | NA |
| GO:0048699 | generation of neurons | NA | NA | 2.06e-02 | NA |
| GO:0007017 | microtubule-based process | NA | NA | 2.11e-02 | NA |
| GO:0007610 | behavior | NA | NA | 2.12e-02 | NA |
| GO:0051179 | localization | NA | NA | 2.12e-02 | NA |
| GO:2000270 | negative regulation of fibroblast apopto... | NA | NA | 2.12e-02 | NA |
| GO:0000281 | mitotic cytokinesis | NA | NA | 2.13e-02 | NA |
| GO:0033365 | protein localization to organelle | NA | NA | 2.21e-02 | NA |
| GO:0019953 | sexual reproduction | NA | NA | 2.41e-02 | NA |
| GO:1905515 | non-motile cilium assembly | NA | NA | 2.52e-02 | NA |
| GO:0010745 | negative regulation of macrophage derive... | NA | NA | 2.59e-02 | NA |
| GO:1902902 | negative regulation of autophagosome ass... | NA | NA | 2.59e-02 | NA |
| GO:0010605 | negative regulation of macromolecule met... | NA | NA | 2.61e-02 | NA |
| GO:0009896 | positive regulation of catabolic process | NA | NA | 2.83e-02 | NA |
| GO:0007276 | gamete generation | NA | NA | 2.83e-02 | NA |
| GO:1901072 | glucosamine-containing compound cataboli... | NA | NA | 2.84e-02 | NA |
| GO:0090025 | regulation of monocyte chemotaxis | NA | NA | 2.85e-02 | NA |
| GO:0006892 | post-Golgi vesicle-mediated transport | NA | NA | 2.85e-02 | NA |
| GO:0051650 | establishment of vesicle localization | NA | NA | 2.98e-02 | NA |
| GO:0016236 | macroautophagy | NA | NA | 3.00e-02 | NA |
| GO:0000045 | autophagosome assembly | NA | NA | 3.03e-02 | NA |
| GO:0051648 | vesicle localization | NA | NA | 3.07e-02 | NA |
| GO:0051177 | meiotic sister chromatid cohesion | NA | NA | 3.15e-02 | NA |
| GO:0022008 | neurogenesis | NA | NA | 3.18e-02 | NA |
| GO:0010558 | negative regulation of macromolecule bio... | NA | NA | 3.26e-02 | NA |
| GO:0009894 | regulation of catabolic process | NA | NA | 3.36e-02 | NA |
| GO:0036289 | peptidyl-serine autophosphorylation | NA | NA | 3.58e-02 | NA |
| GO:1903421 | regulation of synaptic vesicle recycling | NA | NA | 3.68e-02 | NA |
| GO:0072001 | renal system development | NA | NA | 3.92e-02 | NA |
| GO:0007059 | chromosome segregation | NA | NA | 3.92e-02 | NA |
| GO:0022402 | cell cycle process | NA | NA | 4.07e-02 | NA |
| GO:0000425 | pexophagy | NA | NA | 4.14e-02 | NA |
| GO:0060914 | heart formation | NA | NA | 4.14e-02 | NA |
| GO:0099504 | synaptic vesicle cycle | NA | NA | 4.19e-02 | NA |
| GO:0048666 | neuron development | NA | NA | 4.20e-02 | NA |
| GO:0007283 | spermatogenesis | NA | NA | 4.20e-02 | NA |
| GO:0021953 | central nervous system neuron differenti... | NA | NA | 4.31e-02 | NA |
| GO:0048468 | cell development | NA | NA | 4.34e-02 | NA |
| GO:0007049 | cell cycle | NA | NA | 4.49e-02 | NA |
| GO:0090026 | positive regulation of monocyte chemotax... | NA | NA | 4.50e-02 | NA |
| GO:0031327 | negative regulation of cellular biosynth... | NA | NA | 4.50e-02 | NA |
| GO:0010742 | macrophage derived foam cell differentia... | NA | NA | 4.50e-02 | NA |
| GO:0001822 | kidney development | NA | NA | 4.71e-02 | NA |
| GO:0048232 | male gamete generation | NA | NA | 4.77e-02 | NA |
| GO:0042254 | ribosome biogenesis | NA | NA | NA | 2.93e-04 |
| GO:0016072 | rRNA metabolic process | NA | NA | NA | 2.93e-04 |
| GO:0000727 | double-strand break repair via break-ind... | NA | NA | NA | 5.10e-04 |
| GO:0044281 | small molecule metabolic process | NA | NA | NA | 5.10e-04 |
| GO:0006753 | nucleoside phosphate metabolic process | NA | NA | NA | 5.10e-04 |
| GO:0055086 | nucleobase-containing small molecule met... | NA | NA | NA | 5.10e-04 |
| GO:0006364 | rRNA processing | NA | NA | NA | 5.10e-04 |
| GO:0009260 | ribonucleotide biosynthetic process | NA | NA | NA | 5.31e-04 |
| GO:0022613 | ribonucleoprotein complex biogenesis | NA | NA | NA | 5.31e-04 |
| GO:0009142 | nucleoside triphosphate biosynthetic pro... | NA | NA | NA | 1.12e-03 |
| GO:0046390 | ribose phosphate biosynthetic process | NA | NA | NA | 1.12e-03 |
| GO:0017004 | cytochrome complex assembly | NA | NA | NA | 1.14e-03 |
| GO:0009117 | nucleotide metabolic process | NA | NA | NA | 1.17e-03 |
| GO:0009141 | nucleoside triphosphate metabolic proces... | NA | NA | NA | 1.44e-03 |
| GO:0006091 | generation of precursor metabolites and ... | NA | NA | NA | 1.46e-03 |
| GO:0009199 | ribonucleoside triphosphate metabolic pr... | NA | NA | NA | 1.46e-03 |
| GO:0009201 | ribonucleoside triphosphate biosynthetic... | NA | NA | NA | 1.72e-03 |
| GO:0170036 | import into the mitochondrion | NA | NA | NA | 2.12e-03 |
| GO:0009205 | purine ribonucleoside triphosphate metab... | NA | NA | NA | 2.74e-03 |
| GO:0019677 | NAD catabolic process | NA | NA | NA | 2.74e-03 |
| GO:0009259 | ribonucleotide metabolic process | NA | NA | NA | 2.97e-03 |
| GO:0006399 | tRNA metabolic process | NA | NA | NA | 3.02e-03 |
| GO:0009144 | purine nucleoside triphosphate metabolic... | NA | NA | NA | 3.02e-03 |
| GO:0019693 | ribose phosphate metabolic process | NA | NA | NA | 3.02e-03 |
| GO:1901293 | nucleoside phosphate biosynthetic proces... | NA | NA | NA | 3.02e-03 |
| GO:0006560 | proline metabolic process | NA | NA | NA | 3.13e-03 |
| GO:0009152 | purine ribonucleotide biosynthetic proce... | NA | NA | NA | 3.27e-03 |
| GO:0006735 | NADH regeneration | NA | NA | NA | 3.27e-03 |
| GO:0061621 | canonical glycolysis | NA | NA | NA | 3.27e-03 |
| GO:0061718 | glucose catabolic process to pyruvate | NA | NA | NA | 3.27e-03 |
| GO:0003084 | positive regulation of systemic arterial... | NA | NA | NA | 3.30e-03 |
| GO:0046034 | ATP metabolic process | NA | NA | NA | 3.53e-03 |
| GO:0009206 | purine ribonucleoside triphosphate biosy... | NA | NA | NA | 3.87e-03 |
| GO:0008033 | tRNA processing | NA | NA | NA | 4.45e-03 |
| GO:0019637 | organophosphate metabolic process | NA | NA | NA | 4.90e-03 |
| GO:0061620 | glycolytic process through glucose-6-pho... | NA | NA | NA | 5.31e-03 |
| GO:0009145 | purine nucleoside triphosphate biosynthe... | NA | NA | NA | 5.32e-03 |
| GO:0009165 | nucleotide biosynthetic process | NA | NA | NA | 5.32e-03 |
| GO:0072521 | purine-containing compound metabolic pro... | NA | NA | NA | 5.98e-03 |
| GO:0006271 | DNA strand elongation involved in DNA re... | NA | NA | NA | 7.78e-03 |
| GO:0006220 | pyrimidine nucleotide metabolic process | NA | NA | NA | 8.76e-03 |
| GO:0033617 | mitochondrial cytochrome c oxidase assem... | NA | NA | NA | 9.24e-03 |
| GO:0006270 | DNA replication initiation | NA | NA | NA | 1.08e-02 |
| GO:0009150 | purine ribonucleotide metabolic process | NA | NA | NA | 1.09e-02 |
| GO:0009148 | pyrimidine nucleoside triphosphate biosy... | NA | NA | NA | 1.37e-02 |
| GO:0042274 | ribosomal small subunit biogenesis | NA | NA | NA | 1.43e-02 |
| GO:0009147 | pyrimidine nucleoside triphosphate metab... | NA | NA | NA | 1.43e-02 |
| GO:0072527 | pyrimidine-containing compound metabolic... | NA | NA | NA | 1.43e-02 |
| GO:0061615 | glycolytic process through fructose-6-ph... | NA | NA | NA | 1.43e-02 |
| GO:0009219 | pyrimidine deoxyribonucleotide metabolic... | NA | NA | NA | 1.48e-02 |
| GO:0006561 | proline biosynthetic process | NA | NA | NA | 1.58e-02 |
| GO:0055129 | L-proline biosynthetic process | NA | NA | NA | 1.58e-02 |
| GO:0009220 | pyrimidine ribonucleotide biosynthetic p... | NA | NA | NA | 1.61e-02 |
| GO:0072522 | purine-containing compound biosynthetic ... | NA | NA | NA | 1.77e-02 |
| GO:1990542 | mitochondrial transmembrane transport | NA | NA | NA | 1.77e-02 |
| GO:0006261 | DNA-templated DNA replication | NA | NA | NA | 1.87e-02 |
| GO:0030174 | regulation of DNA-templated DNA replicat... | NA | NA | NA | 2.20e-02 |
| GO:1902075 | cellular response to salt | NA | NA | NA | 2.20e-02 |
| GO:1903935 | response to sodium arsenite | NA | NA | NA | 2.20e-02 |
| GO:1903936 | cellular response to sodium arsenite | NA | NA | NA | 2.20e-02 |
| GO:0008535 | respiratory chain complex IV assembly | NA | NA | NA | 2.20e-02 |
| GO:0090407 | organophosphate biosynthetic process | NA | NA | NA | 2.28e-02 |
| GO:0006163 | purine nucleotide metabolic process | NA | NA | NA | 2.29e-02 |
| GO:0006268 | DNA unwinding involved in DNA replicatio... | NA | NA | NA | 2.50e-02 |
| GO:0006164 | purine nucleotide biosynthetic process | NA | NA | NA | 2.98e-02 |
| GO:0043414 | macromolecule methylation | NA | NA | NA | 2.98e-02 |
| GO:0090329 | regulation of DNA-templated DNA replicat... | NA | NA | NA | 3.04e-02 |
| GO:0044283 | small molecule biosynthetic process | NA | NA | NA | 3.22e-02 |
| GO:0009218 | pyrimidine ribonucleotide metabolic proc... | NA | NA | NA | 3.55e-02 |
| GO:0010155 | regulation of proton transport | NA | NA | NA | 4.38e-02 |
| GO:0006066 | alcohol metabolic process | NA | NA | NA | 4.55e-02 |
| GO.ID | Term | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|---|
| GO:0006261 | DNA-templated DNA replication | NA | 4.5e-02 | NA |
| GO:0002181 | cytoplasmic translation | NA | NA | 1.74e-02 |
| GO.ID | Term | positive.PC.1 | negative.PC.1 | positive.PC.2 | negative.PC.2 |
|---|---|---|---|---|---|
| GO:0032787 | monocarboxylic acid metabolic process | 1.76e-18 | NA | NA | NA |
| GO:0006631 | fatty acid metabolic process | 2.73e-18 | NA | NA | NA |
| GO:0051607 | defense response to virus | 2.73e-18 | NA | NA | NA |
| GO:0016053 | organic acid biosynthetic process | 2.73e-18 | NA | NA | NA |
| GO:0046394 | carboxylic acid biosynthetic process | 2.73e-18 | NA | NA | NA |
| GO:0006082 | organic acid metabolic process | 3.89e-18 | NA | NA | NA |
| GO:0043436 | oxoacid metabolic process | 3.89e-18 | NA | NA | NA |
| GO:0016197 | endosomal transport | 5.01e-18 | NA | NA | NA |
| GO:0006633 | fatty acid biosynthetic process | 1.44e-17 | NA | NA | NA |
| GO:0072330 | monocarboxylic acid biosynthetic process | 1.44e-17 | NA | NA | NA |
| GO:0019752 | carboxylic acid metabolic process | 1.45e-17 | NA | NA | NA |
| GO:0009615 | response to virus | 2.30e-17 | NA | NA | NA |
| GO:0008610 | lipid biosynthetic process | 1.39e-16 | NA | NA | NA |
| GO:0033559 | unsaturated fatty acid metabolic process | 5.28e-16 | NA | NA | NA |
| GO:2001233 | regulation of apoptotic signaling pathwa... | 3.77e-15 | NA | NA | NA |
| GO:0016055 | Wnt signaling pathway | 1.36e-14 | NA | NA | NA |
| GO:0030111 | regulation of Wnt signaling pathway | 1.36e-14 | NA | NA | NA |
| GO:0006886 | intracellular protein transport | 1.36e-14 | NA | NA | NA |
| GO:2001234 | negative regulation of apoptotic signali... | 1.83e-14 | NA | NA | NA |
| GO:0044089 | positive regulation of cellular componen... | 3.29e-14 | NA | NA | NA |
| GO:0002495 | antigen processing and presentation of p... | 4.78e-14 | NA | NA | NA |
| GO:0002504 | antigen processing and presentation of p... | 4.78e-14 | NA | NA | NA |
| GO:0019886 | antigen processing and presentation of e... | 4.78e-14 | NA | NA | NA |
| GO:0030335 | positive regulation of cell migration | 1.16e-13 | NA | NA | NA |
| GO:2000147 | positive regulation of cell motility | 1.16e-13 | NA | NA | NA |
| GO:1990845 | adaptive thermogenesis | 1.65e-13 | NA | NA | NA |
| GO:0001906 | cell killing | 4.08e-13 | NA | NA | NA |
| GO:0030334 | regulation of cell migration | 4.67e-13 | NA | NA | NA |
| GO:2000145 | regulation of cell motility | 4.67e-13 | NA | NA | NA |
| GO:0050821 | protein stabilization | 6.15e-13 | NA | NA | NA |
| GO:0006790 | sulfur compound metabolic process | 1.09e-12 | NA | NA | NA |
| GO:0072594 | establishment of protein localization to... | 1.10e-12 | NA | NA | NA |
| GO:0019884 | antigen processing and presentation of e... | 1.60e-12 | NA | NA | NA |
| GO:0070201 | regulation of establishment of protein l... | 1.67e-12 | NA | NA | NA |
| GO:0097193 | intrinsic apoptotic signaling pathway | 2.95e-12 | NA | NA | NA |
| GO:0002697 | regulation of immune effector process | 5.83e-12 | NA | NA | NA |
| GO:0001659 | temperature homeostasis | 7.98e-12 | NA | NA | NA |
| GO:0002478 | antigen processing and presentation of e... | 1.23e-11 | NA | NA | NA |
| GO:0048002 | antigen processing and presentation of p... | 1.23e-11 | NA | NA | NA |
| GO:0097529 | myeloid leukocyte migration | 1.45e-11 | NA | NA | NA |
| GO:1904951 | positive regulation of establishment of ... | 1.51e-11 | NA | NA | NA |
| GO:2001236 | regulation of extrinsic apoptotic signal... | 2.43e-11 | NA | NA | NA |
| GO:0002263 | cell activation involved in immune respo... | 1.78e-10 | NA | NA | NA |
| GO:0002366 | leukocyte activation involved in immune ... | 1.78e-10 | NA | NA | NA |
| GO:0019079 | viral genome replication | 1.96e-10 | NA | NA | NA |
| GO:0097530 | granulocyte migration | 2.52e-10 | NA | NA | NA |
| GO:0007169 | cell surface receptor protein tyrosine k... | 2.53e-10 | NA | NA | NA |
| GO:0002274 | myeloid leukocyte activation | 2.99e-10 | NA | NA | NA |
| GO:0006694 | steroid biosynthetic process | 4.78e-10 | NA | NA | NA |
| GO:0006937 | regulation of muscle contraction | 5.00e-10 | NA | NA | NA |
| GO:0030595 | leukocyte chemotaxis | 5.33e-10 | NA | NA | NA |
| GO:0019216 | regulation of lipid metabolic process | 9.33e-10 | NA | NA | NA |
| GO:0071621 | granulocyte chemotaxis | 9.33e-10 | NA | NA | NA |
| GO:2001242 | regulation of intrinsic apoptotic signal... | 1.44e-09 | NA | NA | NA |
| GO:0002526 | acute inflammatory response | 1.44e-09 | NA | NA | NA |
| GO:0052548 | regulation of endopeptidase activity | 1.48e-09 | NA | NA | NA |
| GO:0031960 | response to corticosteroid | 2.09e-09 | NA | NA | NA |
| GO:0051384 | response to glucocorticoid | 2.09e-09 | NA | NA | NA |
| GO:0048608 | reproductive structure development | 2.09e-09 | NA | NA | NA |
| GO:0061458 | reproductive system development | 2.09e-09 | NA | NA | NA |
| GO:0051223 | regulation of protein transport | 2.64e-09 | NA | NA | NA |
| GO:0097191 | extrinsic apoptotic signaling pathway | 3.84e-09 | NA | NA | NA |
| GO:2001243 | negative regulation of intrinsic apoptot... | 6.26e-09 | NA | NA | NA |
| GO:0090407 | organophosphate biosynthetic process | 1.08e-08 | NA | NA | NA |
| GO:1904062 | regulation of monoatomic cation transmem... | 1.54e-08 | NA | NA | NA |
| GO:0001763 | morphogenesis of a branching structure | 2.65e-08 | NA | NA | NA |
| GO:0061138 | morphogenesis of a branching epithelium | 2.65e-08 | NA | NA | NA |
| GO:0007565 | female pregnancy | 4.22e-08 | NA | NA | NA |
| GO:0044703 | multi-organism reproductive process | 4.22e-08 | NA | NA | NA |
| GO:0044706 | multi-multicellular organism process | 4.22e-08 | NA | NA | NA |
| GO:0032970 | regulation of actin filament-based proce... | 7.41e-08 | NA | NA | NA |
| GO:0031640 | killing of cells of another organism | 7.41e-08 | NA | NA | NA |
| GO:0141060 | disruption of anatomical structure in an... | 7.41e-08 | NA | NA | NA |
| GO:0141061 | disruption of cell in another organism | 7.41e-08 | NA | NA | NA |
| GO:0010810 | regulation of cell-substrate adhesion | 7.71e-08 | NA | NA | NA |
| GO:1990266 | neutrophil migration | 9.69e-08 | NA | NA | NA |
| GO:0051222 | positive regulation of protein transport | 1.23e-07 | NA | NA | NA |
| GO:0045766 | positive regulation of angiogenesis | 3.97e-07 | NA | NA | NA |
| GO:1904018 | positive regulation of vasculature devel... | 3.97e-07 | NA | NA | NA |
| GO:0032388 | positive regulation of intracellular tra... | 7.88e-07 | NA | NA | NA |
| GO:0070371 | ERK1 and ERK2 cascade | 1.26e-06 | NA | NA | NA |
| GO:0050727 | regulation of inflammatory response | 1.37e-06 | NA | NA | NA |
| GO:0001890 | placenta development | 1.98e-06 | NA | NA | NA |
| GO:0010951 | negative regulation of endopeptidase act... | 2.64e-06 | NA | NA | NA |
| GO:1901342 | regulation of vasculature development | 3.03e-06 | NA | NA | NA |
| GO:0006605 | protein targeting | 8.33e-06 | NA | NA | NA |
| GO:0015850 | organic hydroxy compound transport | 1.17e-05 | NA | NA | NA |
| GO:0006869 | lipid transport | 1.69e-05 | NA | NA | NA |
| GO:0010876 | lipid localization | 1.69e-05 | NA | NA | NA |
| GO:0043281 | regulation of cysteine-type endopeptidas... | 2.24e-05 | NA | NA | NA |
| GO:2000116 | regulation of cysteine-type endopeptidas... | 2.24e-05 | NA | NA | NA |
| GO:0034764 | positive regulation of transmembrane tra... | 4.62e-05 | NA | NA | NA |
| GO:0006575 | cellular modified amino acid metabolic p... | 6.22e-05 | NA | NA | NA |
| GO:0045765 | regulation of angiogenesis | 6.58e-05 | NA | NA | NA |
| GO:0050673 | epithelial cell proliferation | 8.58e-05 | NA | NA | NA |
| GO:0050678 | regulation of epithelial cell proliferat... | 8.58e-05 | NA | NA | NA |
| GO:0033077 | T cell differentiation in thymus | 1.07e-04 | NA | NA | NA |
| GO:0032956 | regulation of actin cytoskeleton organiz... | 1.81e-04 | NA | NA | NA |
| GO:0048754 | branching morphogenesis of an epithelial... | 2.50e-04 | NA | NA | NA |
| GO:1902903 | regulation of supramolecular fiber organ... | 2.59e-04 | NA | NA | NA |
| GO:0045165 | cell fate commitment | 3.21e-04 | NA | NA | NA |
| GO:0098739 | import across plasma membrane | 3.26e-04 | NA | NA | NA |
| GO:0040013 | negative regulation of locomotion | 7.06e-04 | NA | NA | NA |
| GO:2000146 | negative regulation of cell motility | 7.06e-04 | NA | NA | NA |
| GO:0110053 | regulation of actin filament organizatio... | 2.88e-03 | NA | NA | NA |
| GO:0097190 | apoptotic signaling pathway | 6.92e-03 | NA | NA | NA |
| GO:0006954 | inflammatory response | 1.49e-02 | NA | NA | NA |
| GO:0040012 | regulation of locomotion | 1.62e-02 | NA | NA | NA |
| GO:0043069 | negative regulation of programmed cell d... | 2.13e-02 | NA | NA | NA |
| GO:0006952 | defense response | 2.52e-02 | NA | NA | NA |
| GO:0006955 | immune response | 2.72e-02 | NA | NA | NA |
| GO:0098657 | import into cell | 2.91e-02 | NA | NA | NA |
| GO:0043066 | negative regulation of apoptotic process | 3.52e-02 | NA | NA | NA |
| GO:0097237 | cellular response to toxic substance | NA | NA | 7.18e-04 | NA |
| GO:0098754 | detoxification | NA | NA | 7.18e-04 | NA |
| GO:1990748 | cellular detoxification | NA | NA | 7.18e-04 | NA |
| GO:1901888 | regulation of cell junction assembly | NA | NA | 3.41e-02 | NA |
| GO:0048513 | animal organ development | NA | NA | NA | 2.73e-02 |
| GO:0032502 | developmental process | NA | NA | NA | 2.73e-02 |
| GO:0048856 | anatomical structure development | NA | NA | NA | 4.63e-02 |
| GO:0009653 | anatomical structure morphogenesis | NA | NA | NA | 4.63e-02 |
| GO.ID | Term | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|---|
| GO:0006091 | generation of precursor metabolites and ... | 7.63e-05 | NA | NA |
| GO:2001236 | regulation of extrinsic apoptotic signal... | 1.52e-04 | NA | NA |
| GO:0071356 | cellular response to tumor necrosis fact... | 4.59e-04 | NA | NA |
| GO:0008380 | RNA splicing | 4.59e-04 | NA | NA |
| GO:0051302 | regulation of cell division | 5.74e-04 | NA | NA |
| GO:0097435 | supramolecular fiber organization | 9.09e-03 | NA | NA |
| GO.ID | Term | positive.PC.1 | negative.PC.1 | positive.PC.2 | negative.PC.2 |
|---|---|---|---|---|---|
| GO:0022625 | cytosolic large ribosomal subunit | 2.16e-74 | NA | NA | 4.93e-03 |
| GO:0044391 | ribosomal subunit | 1.54e-45 | NA | NA | 4.50e-03 |
| GO:0005840 | ribosome | 3.83e-30 | NA | NA | 3.45e-02 |
| GO:0022626 | cytosolic ribosome | 1.03e-29 | NA | NA | NA |
| GO:0070062 | extracellular exosome | 1.64e-29 | NA | NA | NA |
| GO:1903561 | extracellular vesicle | 1.64e-29 | NA | NA | NA |
| GO:0015934 | large ribosomal subunit | 1.64e-29 | NA | NA | 4.50e-03 |
| GO:0043230 | extracellular organelle | 1.64e-29 | NA | NA | NA |
| GO:0065010 | extracellular membrane-bounded organelle | 1.64e-29 | NA | NA | NA |
| GO:0005615 | extracellular space | 1.22e-25 | NA | NA | NA |
| GO:0005576 | extracellular region | 3.53e-24 | NA | NA | NA |
| GO:0022627 | cytosolic small ribosomal subunit | 4.72e-19 | NA | NA | NA |
| GO:0015935 | small ribosomal subunit | 7.37e-17 | NA | NA | NA |
| GO:0042613 | MHC class II protein complex | 3.05e-15 | NA | NA | NA |
| GO:0031982 | vesicle | 4.38e-14 | NA | NA | NA |
| GO:0005783 | endoplasmic reticulum | 1.45e-12 | NA | NA | NA |
| GO:1990904 | ribonucleoprotein complex | 5.72e-10 | NA | NA | 1.43e-02 |
| GO:0005789 | endoplasmic reticulum membrane | 5.88e-10 | NA | NA | NA |
| GO:0098827 | endoplasmic reticulum subcompartment | 6.50e-10 | NA | NA | NA |
| GO:0031090 | organelle membrane | 8.02e-10 | NA | NA | NA |
| GO:0042175 | nuclear outer membrane-endoplasmic retic... | 1.03e-09 | NA | NA | NA |
| GO:0042611 | MHC protein complex | 1.67e-09 | NA | NA | NA |
| GO:0098796 | membrane protein complex | 2.00e-09 | NA | NA | NA |
| GO:0098798 | mitochondrial protein-containing complex | 3.04e-09 | NA | NA | 4.27e-03 |
| GO:0019866 | organelle inner membrane | 4.29e-09 | NA | NA | 4.31e-10 |
| GO:0005743 | mitochondrial inner membrane | 1.10e-08 | NA | NA | 1.12e-10 |
| GO:0005740 | mitochondrial envelope | 2.45e-08 | NA | NA | 1.07e-06 |
| GO:0000313 | organellar ribosome | 3.09e-08 | NA | NA | NA |
| GO:0005761 | mitochondrial ribosome | 3.09e-08 | NA | NA | NA |
| GO:0031966 | mitochondrial membrane | 3.91e-08 | NA | NA | 3.38e-06 |
| GO:0030141 | secretory granule | 9.01e-08 | NA | NA | NA |
| GO:0000315 | organellar large ribosomal subunit | 2.98e-07 | NA | NA | NA |
| GO:0005762 | mitochondrial large ribosomal subunit | 2.98e-07 | NA | NA | NA |
| GO:0140534 | endoplasmic reticulum protein-containing... | 2.40e-06 | NA | NA | NA |
| GO:0012505 | endomembrane system | 2.44e-06 | NA | NA | NA |
| GO:0005739 | mitochondrion | 3.09e-06 | NA | NA | 6.32e-07 |
| GO:0005925 | focal adhesion | 5.13e-06 | NA | NA | 4.58e-02 |
| GO:0099503 | secretory vesicle | 5.14e-06 | NA | NA | NA |
| GO:0031984 | organelle subcompartment | 6.66e-06 | NA | NA | NA |
| GO:0030055 | cell-substrate junction | 6.66e-06 | NA | NA | 4.58e-02 |
| GO:0031967 | organelle envelope | 1.01e-05 | NA | NA | 2.78e-03 |
| GO:0016020 | membrane | 1.29e-05 | NA | NA | NA |
| GO:0005766 | primary lysosome | 2.07e-05 | NA | NA | NA |
| GO:0042582 | azurophil granule | 2.07e-05 | NA | NA | NA |
| GO:0005839 | proteasome core complex | 3.25e-05 | NA | NA | NA |
| GO:0030662 | coated vesicle membrane | 4.93e-05 | NA | NA | NA |
| GO:0005834 | heterotrimeric G-protein complex | 5.09e-05 | NA | NA | NA |
| GO:0030134 | COPII-coated ER to Golgi transport vesic... | 6.60e-05 | NA | NA | NA |
| GO:0120115 | Lsm2-8 complex | 7.76e-05 | NA | NA | NA |
| GO:0005683 | U7 snRNP | 8.94e-05 | NA | NA | NA |
| GO:0035577 | azurophil granule membrane | 9.27e-05 | NA | NA | NA |
| GO:0032991 | protein-containing complex | 9.27e-05 | NA | NA | NA |
| GO:0042470 | melanosome | 1.32e-04 | NA | NA | NA |
| GO:0048770 | pigment granule | 1.32e-04 | NA | NA | NA |
| GO:0030135 | coated vesicle | 2.72e-04 | NA | NA | NA |
| GO:0012507 | ER to Golgi transport vesicle membrane | 2.72e-04 | NA | NA | NA |
| GO:0005787 | signal peptidase complex | 3.03e-04 | NA | NA | NA |
| GO:0043505 | CENP-A containing nucleosome | 3.03e-04 | NA | NA | NA |
| GO:0061638 | CENP-A containing chromatin | 3.03e-04 | NA | NA | NA |
| GO:0000323 | lytic vacuole | 3.29e-04 | NA | 1.57e-03 | NA |
| GO:0005764 | lysosome | 3.29e-04 | NA | 1.57e-03 | NA |
| GO:1990726 | Lsm1-7-Pat1 complex | 4.12e-04 | NA | NA | NA |
| GO:0000139 | Golgi membrane | 4.64e-04 | NA | NA | NA |
| GO:0098553 | lumenal side of endoplasmic reticulum me... | 4.86e-04 | NA | NA | NA |
| GO:0098556 | cytoplasmic side of rough endoplasmic re... | 5.04e-04 | NA | NA | NA |
| GO:0000314 | organellar small ribosomal subunit | 6.90e-04 | NA | NA | NA |
| GO:0005763 | mitochondrial small ribosomal subunit | 6.90e-04 | NA | NA | NA |
| GO:0000502 | proteasome complex | 6.90e-04 | NA | NA | NA |
| GO:0030133 | transport vesicle | 8.53e-04 | NA | 1.57e-03 | NA |
| GO:0031983 | vesicle lumen | 8.54e-04 | NA | NA | NA |
| GO:0060205 | cytoplasmic vesicle lumen | 8.54e-04 | NA | NA | NA |
| GO:0098552 | side of membrane | 8.54e-04 | NA | NA | NA |
| GO:0030667 | secretory granule membrane | 8.99e-04 | NA | NA | NA |
| GO:0098588 | bounding membrane of organelle | 9.58e-04 | NA | NA | NA |
| GO:0098803 | respiratory chain complex | 9.58e-04 | NA | NA | 5.15e-03 |
| GO:0005759 | mitochondrial matrix | 9.88e-04 | NA | NA | 4.56e-04 |
| GO:1905360 | GTPase complex | 9.88e-04 | NA | NA | NA |
| GO:0034774 | secretory granule lumen | 9.99e-04 | NA | NA | NA |
| GO:0001772 | immunological synapse | 1.31e-03 | NA | NA | NA |
| GO:1905369 | endopeptidase complex | 1.35e-03 | NA | NA | NA |
| GO:0008250 | oligosaccharyltransferase complex | 1.64e-03 | NA | NA | NA |
| GO:0031902 | late endosome membrane | 1.70e-03 | NA | 2.51e-03 | NA |
| GO:0019773 | proteasome core complex, alpha-subunit c... | 1.84e-03 | NA | NA | NA |
| GO:0009986 | cell surface | 1.85e-03 | NA | NA | NA |
| GO:0098857 | membrane microdomain | 1.87e-03 | NA | NA | NA |
| GO:0030669 | clathrin-coated endocytic vesicle membra... | 1.89e-03 | NA | NA | NA |
| GO:0016469 | proton-transporting two-sector ATPase co... | 1.92e-03 | NA | NA | NA |
| GO:0030666 | endocytic vesicle membrane | 2.58e-03 | NA | NA | NA |
| GO:0070820 | tertiary granule | 3.00e-03 | NA | NA | NA |
| GO:0045121 | membrane raft | 3.47e-03 | NA | NA | NA |
| GO:0005775 | vacuolar lumen | 3.48e-03 | NA | NA | NA |
| GO:0043227 | membrane-bounded organelle | 3.49e-03 | NA | NA | NA |
| GO:0005773 | vacuole | 4.00e-03 | NA | 4.50e-04 | NA |
| GO:0000786 | nucleosome | 4.09e-03 | NA | 6.00e-05 | NA |
| GO:0097197 | tetraspanin-enriched microdomain | 4.42e-03 | NA | NA | NA |
| GO:0030670 | phagocytic vesicle membrane | 4.61e-03 | NA | NA | NA |
| GO:0030659 | cytoplasmic vesicle membrane | 4.88e-03 | NA | NA | NA |
| GO:0101002 | ficolin-1-rich granule | 4.88e-03 | NA | NA | NA |
| GO:0034715 | pICln-Sm protein complex | 4.88e-03 | NA | NA | NA |
| GO:0043231 | intracellular membrane-bounded organelle | 5.67e-03 | NA | NA | NA |
| GO:0005791 | rough endoplasmic reticulum | 6.67e-03 | NA | NA | NA |
| GO:0030665 | clathrin-coated vesicle membrane | 6.67e-03 | NA | NA | NA |
| GO:0005737 | cytoplasm | 6.93e-03 | NA | NA | NA |
| GO:0098576 | lumenal side of membrane | 6.94e-03 | NA | NA | NA |
| GO:0012506 | vesicle membrane | 7.79e-03 | NA | NA | NA |
| GO:0031410 | cytoplasmic vesicle | 8.24e-03 | NA | NA | NA |
| GO:0017059 | serine palmitoyltransferase complex | 9.28e-03 | NA | NA | NA |
| GO:1904813 | ficolin-1-rich granule lumen | 9.33e-03 | NA | NA | NA |
| GO:1904724 | tertiary granule lumen | 9.44e-03 | NA | NA | NA |
| GO:0072562 | blood microparticle | 9.75e-03 | NA | NA | NA |
| GO:0005885 | Arp2/3 protein complex | 9.98e-03 | NA | NA | NA |
| GO:1990351 | transporter complex | 1.08e-02 | NA | NA | NA |
| GO:0045334 | clathrin-coated endocytic vesicle | 1.08e-02 | NA | NA | NA |
| GO:0005758 | mitochondrial intermembrane space | 1.08e-02 | NA | NA | NA |
| GO:0097708 | intracellular vesicle | 1.13e-02 | NA | NA | NA |
| GO:0009897 | external side of plasma membrane | 1.29e-02 | NA | NA | NA |
| GO:0005688 | U6 snRNP | 1.30e-02 | NA | NA | NA |
| GO:0090533 | cation-transporting ATPase complex | 1.30e-02 | NA | NA | NA |
| GO:0005765 | lysosomal membrane | 1.37e-02 | NA | 4.12e-02 | NA |
| GO:0098852 | lytic vacuole membrane | 1.37e-02 | NA | 4.12e-02 | NA |
| GO:0001405 | PAM complex, Tim23 associated import mot... | 1.40e-02 | NA | NA | NA |
| GO:0045335 | phagocytic vesicle | 1.42e-02 | NA | NA | NA |
| GO:0034506 | chromosome, centromeric core domain | 1.69e-02 | NA | NA | NA |
| GO:0005838 | proteasome regulatory particle | 1.81e-02 | NA | NA | NA |
| GO:0002178 | palmitoyltransferase complex | 1.81e-02 | NA | NA | NA |
| GO:0033178 | proton-transporting two-sector ATPase co... | 1.89e-02 | NA | NA | NA |
| GO:0005744 | TIM23 mitochondrial import inner membran... | 1.90e-02 | NA | NA | 2.16e-02 |
| GO:0031234 | extrinsic component of cytoplasmic side ... | 2.05e-02 | NA | NA | NA |
| GO:0033116 | endoplasmic reticulum-Golgi intermediate... | 2.05e-02 | NA | NA | NA |
| GO:0071204 | histone pre-mRNA 3'end processing comple... | 2.07e-02 | NA | NA | NA |
| GO:0005774 | vacuolar membrane | 2.19e-02 | NA | 1.80e-02 | NA |
| GO:0019774 | proteasome core complex, beta-subunit co... | 2.25e-02 | NA | NA | NA |
| GO:0035578 | azurophil granule lumen | 2.32e-02 | NA | NA | NA |
| GO:1902495 | transmembrane transporter complex | 2.37e-02 | NA | NA | NA |
| GO:0030663 | COPI-coated vesicle membrane | 2.56e-02 | NA | NA | NA |
| GO:0030658 | transport vesicle membrane | 2.63e-02 | NA | 3.22e-02 | NA |
| GO:0140596 | TOM complex | 2.77e-02 | NA | NA | NA |
| GO:0098797 | plasma membrane protein complex | 2.77e-02 | NA | NA | NA |
| GO:1905368 | peptidase complex | 2.79e-02 | NA | NA | NA |
| GO:0030867 | rough endoplasmic reticulum membrane | 2.79e-02 | NA | NA | NA |
| GO:0008290 | F-actin capping protein complex | 2.82e-02 | NA | NA | NA |
| GO:0072546 | EMC complex | 2.83e-02 | NA | NA | NA |
| GO:0042612 | MHC class I protein complex | 2.90e-02 | NA | NA | NA |
| GO:0070993 | translation preinitiation complex | 3.28e-02 | NA | NA | NA |
| GO:0031970 | organelle envelope lumen | 3.30e-02 | NA | NA | NA |
| GO:0005798 | Golgi-associated vesicle | 3.46e-02 | NA | NA | NA |
| GO:0071007 | U2-type catalytic step 2 spliceosome | 4.13e-02 | NA | NA | NA |
| GO:0030136 | clathrin-coated vesicle | 4.30e-02 | NA | NA | NA |
| GO:0032040 | small-subunit processome | 4.36e-02 | NA | NA | 2.32e-02 |
| GO:0098800 | inner mitochondrial membrane protein com... | 4.41e-02 | NA | NA | 5.15e-03 |
| GO:0033176 | proton-transporting V-type ATPase comple... | 4.71e-02 | NA | NA | NA |
| GO:0005856 | cytoskeleton | NA | 1.54e-05 | 2.00e-02 | NA |
| GO:0015630 | microtubule cytoskeleton | NA | 5.63e-04 | 3.10e-04 | NA |
| GO:0005815 | microtubule organizing center | NA | 1.41e-03 | 9.51e-04 | NA |
| GO:0043194 | axon initial segment | NA | 1.92e-03 | NA | NA |
| GO:0005694 | chromosome | NA | 2.18e-03 | 4.29e-03 | NA |
| GO:0005814 | centriole | NA | 2.26e-03 | 2.97e-03 | NA |
| GO:0036064 | ciliary basal body | NA | 2.91e-03 | NA | NA |
| GO:0016604 | nuclear body | NA | 3.27e-03 | 1.73e-04 | NA |
| GO:0043228 | non-membrane-bounded organelle | NA | 4.33e-03 | NA | NA |
| GO:0043232 | intracellular non-membrane-bounded organ... | NA | 4.33e-03 | NA | NA |
| GO:0016607 | nuclear speck | NA | 5.48e-03 | 1.57e-03 | NA |
| GO:0031931 | TORC1 complex | NA | 5.98e-03 | NA | NA |
| GO:0042995 | cell projection | NA | 7.30e-03 | NA | NA |
| GO:0034451 | centriolar satellite | NA | 8.58e-03 | NA | NA |
| GO:0120025 | plasma membrane bounded cell projection | NA | 1.09e-02 | NA | NA |
| GO:0097427 | microtubule bundle | NA | 1.09e-02 | NA | NA |
| GO:0000785 | chromatin | NA | 1.10e-02 | 1.93e-03 | NA |
| GO:0099738 | cell cortex region | NA | 1.22e-02 | NA | NA |
| GO:0035097 | histone methyltransferase complex | NA | 1.24e-02 | NA | NA |
| GO:0032437 | cuticular plate | NA | 2.12e-02 | NA | NA |
| GO:0048786 | presynaptic active zone | NA | 2.15e-02 | NA | NA |
| GO:0035976 | transcription factor AP-1 complex | NA | 2.27e-02 | NA | NA |
| GO:0043005 | neuron projection | NA | 2.83e-02 | NA | NA |
| GO:0005813 | centrosome | NA | 4.26e-02 | 5.60e-05 | NA |
| GO:0000776 | kinetochore | NA | NA | 2.70e-05 | NA |
| GO:0000775 | chromosome, centromeric region | NA | NA | 2.70e-05 | NA |
| GO:0000779 | condensed chromosome, centromeric region | NA | NA | 2.70e-05 | NA |
| GO:0005770 | late endosome | NA | NA | 3.10e-04 | NA |
| GO:0000922 | spindle pole | NA | NA | 9.34e-04 | NA |
| GO:0005768 | endosome | NA | NA | 1.57e-03 | NA |
| GO:0010008 | endosome membrane | NA | NA | 1.57e-03 | NA |
| GO:0005829 | cytosol | NA | NA | 1.57e-03 | NA |
| GO:0005769 | early endosome | NA | NA | 1.57e-03 | NA |
| GO:0005819 | spindle | NA | NA | 1.57e-03 | NA |
| GO:0031901 | early endosome membrane | NA | NA | 1.57e-03 | NA |
| GO:0005622 | intracellular anatomical structure | NA | NA | 2.16e-03 | NA |
| GO:0005802 | trans-Golgi network | NA | NA | 2.16e-03 | NA |
| GO:0000793 | condensed chromosome | NA | NA | 2.34e-03 | NA |
| GO:0008021 | synaptic vesicle | NA | NA | 2.58e-03 | NA |
| GO:0008278 | cohesin complex | NA | NA | 3.46e-03 | NA |
| GO:0005634 | nucleus | NA | NA | 4.94e-03 | NA |
| GO:0098793 | presynapse | NA | NA | 5.47e-03 | NA |
| GO:0098791 | Golgi apparatus subcompartment | NA | NA | 6.43e-03 | NA |
| GO:0098687 | chromosomal region | NA | NA | 7.71e-03 | NA |
| GO:0005942 | phosphatidylinositol 3-kinase complex | NA | NA | 1.19e-02 | NA |
| GO:0070382 | exocytic vesicle | NA | NA | 1.54e-02 | NA |
| GO:0030892 | mitotic cohesin complex | NA | NA | 1.82e-02 | NA |
| GO:0030496 | midbody | NA | NA | 3.13e-02 | NA |
| GO:0035032 | phosphatidylinositol 3-kinase complex, c... | NA | NA | 3.13e-02 | NA |
| GO:0000407 | phagophore assembly site | NA | NA | 3.13e-02 | NA |
| GO:0005794 | Golgi apparatus | NA | NA | 3.22e-02 | NA |
| GO:0008024 | cyclin/CDK positive transcription elonga... | NA | NA | 3.22e-02 | NA |
| GO:0030672 | synaptic vesicle membrane | NA | NA | 3.58e-02 | NA |
| GO:0099501 | exocytic vesicle membrane | NA | NA | 3.58e-02 | NA |
| GO:0110165 | cellular anatomical entity | NA | NA | 4.05e-02 | NA |
| GO:0098850 | extrinsic component of synaptic vesicle ... | NA | NA | 4.12e-02 | NA |
| GO:0071162 | CMG complex | NA | NA | NA | 1.00e-04 |
| GO:0031261 | DNA replication preinitiation complex | NA | NA | NA | 2.37e-03 |
| GO:0030684 | preribosome | NA | NA | NA | 7.03e-03 |
| GO:0001931 | uropod | NA | NA | NA | 1.08e-02 |
| GO:1990204 | oxidoreductase complex | NA | NA | NA | 1.36e-02 |
| GO:0070069 | cytochrome complex | NA | NA | NA | 3.11e-02 |
| GO:0001725 | stress fiber | NA | NA | NA | 3.29e-02 |
| GO:0097517 | contractile actin filament bundle | NA | NA | NA | 3.29e-02 |
| GO:0005658 | alpha DNA polymerase:primase complex | NA | NA | NA | 4.04e-02 |
| GO.ID | Term | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|---|
| GO:0022626 | cytosolic ribosome | NA | NA | 2.91e-05 |
| GO:0044391 | ribosomal subunit | NA | NA | 3.85e-04 |
| GO:0022625 | cytosolic large ribosomal subunit | NA | NA | 3.85e-04 |
| GO:0031982 | vesicle | NA | NA | 3.85e-04 |
| GO:0005773 | vacuole | NA | NA | 3.85e-04 |
| GO:0012505 | endomembrane system | NA | NA | 3.85e-04 |
| GO:1903561 | extracellular vesicle | NA | NA | 3.85e-04 |
| GO:0043230 | extracellular organelle | NA | NA | 3.85e-04 |
| GO:0065010 | extracellular membrane-bounded organelle | NA | NA | 3.85e-04 |
| GO:0000323 | lytic vacuole | NA | NA | 3.85e-04 |
| GO:0005764 | lysosome | NA | NA | 3.85e-04 |
| GO:0005783 | endoplasmic reticulum | NA | NA | 4.74e-04 |
| GO:0005576 | extracellular region | NA | NA | 5.49e-04 |
| GO:0070062 | extracellular exosome | NA | NA | 5.91e-04 |
| GO:0000775 | chromosome, centromeric region | NA | NA | 8.03e-04 |
| GO:0005615 | extracellular space | NA | NA | 9.05e-04 |
| GO:0005840 | ribosome | NA | NA | 1.18e-03 |
| GO:0000786 | nucleosome | NA | NA | 1.28e-03 |
| GO:0042175 | nuclear outer membrane-endoplasmic retic... | NA | NA | 1.74e-03 |
| GO:0022627 | cytosolic small ribosomal subunit | NA | NA | 2.00e-03 |
| GO:0005789 | endoplasmic reticulum membrane | NA | NA | 3.37e-03 |
| GO:0098827 | endoplasmic reticulum subcompartment | NA | NA | 3.73e-03 |
| GO:0031984 | organelle subcompartment | NA | NA | 4.05e-03 |
| GO:0000793 | condensed chromosome | NA | NA | 4.05e-03 |
| GO:0098588 | bounding membrane of organelle | NA | NA | 5.03e-03 |
| GO:0015935 | small ribosomal subunit | NA | NA | 5.20e-03 |
| GO:0030133 | transport vesicle | NA | NA | 6.03e-03 |
| GO:0005770 | late endosome | NA | NA | 9.06e-03 |
| GO:0031902 | late endosome membrane | NA | NA | 1.13e-02 |
| GO:0030867 | rough endoplasmic reticulum membrane | NA | NA | 1.59e-02 |
| GO:0005774 | vacuolar membrane | NA | NA | 1.59e-02 |
| GO:0005737 | cytoplasm | NA | NA | 2.07e-02 |
| GO:0015934 | large ribosomal subunit | NA | NA | 2.31e-02 |
| GO:0005791 | rough endoplasmic reticulum | NA | NA | 2.39e-02 |
| GO:0097708 | intracellular vesicle | NA | NA | 2.39e-02 |
| GO:0031410 | cytoplasmic vesicle | NA | NA | 2.46e-02 |
| GO:0000779 | condensed chromosome, centromeric region | NA | NA | 2.89e-02 |
| GO:0031090 | organelle membrane | NA | NA | 2.89e-02 |
| GO:0042611 | MHC protein complex | NA | NA | 3.35e-02 |
| GO:0000776 | kinetochore | NA | NA | 3.35e-02 |
| GO:0000139 | Golgi membrane | NA | NA | 3.49e-02 |
| GO:0005775 | vacuolar lumen | NA | NA | 3.71e-02 |
| GO:0000502 | proteasome complex | NA | NA | 3.77e-02 |
| GO:0099503 | secretory vesicle | NA | NA | 3.92e-02 |
| GO:0098796 | membrane protein complex | NA | NA | 4.49e-02 |
| GO:0005765 | lysosomal membrane | NA | NA | 4.74e-02 |
| GO:0098852 | lytic vacuole membrane | NA | NA | 4.74e-02 |
| GO.ID | Term | positive.PC.1 | negative.PC.1 | positive.PC.2 | negative.PC.2 |
|---|---|---|---|---|---|
| GO:0005740 | mitochondrial envelope | 2.82e-23 | NA | NA | NA |
| GO:0031966 | mitochondrial membrane | 2.82e-23 | NA | NA | NA |
| GO:0031967 | organelle envelope | 6.76e-23 | NA | NA | NA |
| GO:0005743 | mitochondrial inner membrane | 7.81e-23 | NA | NA | NA |
| GO:0019866 | organelle inner membrane | 1.61e-22 | NA | NA | NA |
| GO:0005770 | late endosome | 1.69e-22 | NA | NA | NA |
| GO:0030662 | coated vesicle membrane | 1.55e-21 | NA | NA | NA |
| GO:0031902 | late endosome membrane | 1.66e-21 | NA | NA | NA |
| GO:0005759 | mitochondrial matrix | 2.43e-20 | NA | NA | NA |
| GO:0043202 | lysosomal lumen | 2.27e-19 | NA | NA | NA |
| GO:0012507 | ER to Golgi transport vesicle membrane | 8.70e-19 | NA | NA | NA |
| GO:0030665 | clathrin-coated vesicle membrane | 1.86e-18 | NA | NA | NA |
| GO:0032588 | trans-Golgi network membrane | 8.24e-18 | NA | NA | NA |
| GO:0030669 | clathrin-coated endocytic vesicle membra... | 9.00e-16 | NA | NA | NA |
| GO:0045334 | clathrin-coated endocytic vesicle | 9.00e-16 | NA | NA | NA |
| GO:0030666 | endocytic vesicle membrane | 1.02e-15 | NA | NA | NA |
| GO:0042611 | MHC protein complex | 1.23e-12 | NA | NA | NA |
| GO:0042613 | MHC class II protein complex | 1.23e-12 | NA | NA | NA |
| GO:0098553 | lumenal side of endoplasmic reticulum me... | 1.23e-12 | NA | NA | NA |
| GO:0098576 | lumenal side of membrane | 1.23e-12 | NA | NA | NA |
| GO:0005635 | nuclear envelope | 8.10e-11 | NA | NA | NA |
| GO:0016363 | nuclear matrix | 5.15e-10 | NA | NA | NA |
| GO:0000793 | condensed chromosome | 3.83e-06 | NA | NA | NA |
| GO:0005739 | mitochondrion | 1.46e-03 | NA | NA | NA |
| GO:0005765 | lysosomal membrane | 1.09e-02 | NA | NA | NA |
| GO:0005774 | vacuolar membrane | 1.09e-02 | NA | NA | NA |
| GO:0098852 | lytic vacuole membrane | 1.09e-02 | NA | NA | NA |
| GO:0005768 | endosome | 3.77e-02 | NA | NA | NA |
| GO:0071944 | cell periphery | NA | NA | NA | 4.00e-04 |
| GO:0005886 | plasma membrane | NA | NA | NA | 1.38e-03 |
| GO:0098590 | plasma membrane region | NA | NA | NA | 3.48e-02 |
| GO:0005911 | cell-cell junction | NA | NA | NA | 3.48e-02 |
| GO.ID | Term | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|---|
| GO:0005766 | primary lysosome | 8.69e-06 | NA | NA |
| GO:0042582 | azurophil granule | 8.69e-06 | NA | NA |
| GO:0005667 | transcription regulator complex | 1.40e-05 | NA | NA |
| GO:0090575 | RNA polymerase II transcription regulato... | 1.69e-05 | NA | NA |
| GO:0099081 | supramolecular polymer | 3.71e-03 | NA | NA |
| GO:0099512 | supramolecular fiber | 3.71e-03 | NA | NA |
| GO:0005856 | cytoskeleton | 8.51e-03 | NA | NA |
| GO:0016607 | nuclear speck | 1.23e-02 | NA | NA |
| GO:0030863 | cortical cytoskeleton | 3.90e-02 | NA | NA |
| GO:0036477 | somatodendritic compartment | 3.90e-02 | NA | NA |
| GO:0015629 | actin cytoskeleton | 3.96e-02 | NA | NA |
| GO:0030864 | cortical actin cytoskeleton | 4.47e-02 | NA | NA |
| GO:0043228 | non-membrane-bounded organelle | 4.47e-02 | NA | NA |
| GO:0043232 | intracellular non-membrane-bounded organ... | 4.47e-02 | NA | NA |
| GO:0030054 | cell junction | 4.83e-02 | NA | NA |
| GO.ID | Term | positive.PC.1 | negative.PC.1 | positive.PC.2 | negative.PC.2 |
|---|---|---|---|---|---|
| GO:0003735 | structural constituent of ribosome | 1.53e-42 | NA | NA | 2.75e-03 |
| GO:0005198 | structural molecule activity | 3.23e-11 | NA | NA | NA |
| GO:0023026 | MHC class II protein complex binding | 3.23e-11 | NA | NA | NA |
| GO:0019843 | rRNA binding | 5.65e-09 | NA | NA | NA |
| GO:0003924 | GTPase activity | 4.71e-08 | NA | NA | NA |
| GO:0030527 | structural constituent of chromatin | 1.82e-07 | NA | 1.82e-03 | NA |
| GO:0032395 | MHC class II receptor activity | 2.21e-07 | NA | NA | NA |
| GO:0023023 | MHC protein complex binding | 5.95e-06 | NA | NA | NA |
| GO:0019001 | guanyl nucleotide binding | 1.31e-05 | NA | NA | NA |
| GO:0032561 | guanyl ribonucleotide binding | 1.31e-05 | NA | NA | NA |
| GO:0005525 | GTP binding | 1.64e-05 | NA | NA | NA |
| GO:0051920 | peroxiredoxin activity | 2.34e-05 | NA | NA | NA |
| GO:0097177 | mitochondrial ribosome binding | 4.55e-05 | NA | NA | NA |
| GO:0008379 | thioredoxin peroxidase activity | 5.19e-05 | NA | NA | NA |
| GO:0140824 | thioredoxin-dependent peroxiredoxin acti... | 5.19e-05 | NA | NA | NA |
| GO:0019003 | GDP binding | 5.41e-05 | NA | NA | NA |
| GO:0003925 | G protein activity | 7.26e-05 | NA | NA | NA |
| GO:0046982 | protein heterodimerization activity | 2.16e-04 | NA | NA | NA |
| GO:0016209 | antioxidant activity | 2.87e-04 | NA | NA | NA |
| GO:0042605 | peptide antigen binding | 6.09e-04 | NA | NA | NA |
| GO:0003823 | antigen binding | 1.16e-03 | NA | NA | NA |
| GO:0008430 | selenium binding | 1.60e-03 | NA | NA | NA |
| GO:0042287 | MHC protein binding | 1.89e-03 | NA | NA | NA |
| GO:0003723 | RNA binding | 2.65e-03 | NA | NA | NA |
| GO:0061650 | ubiquitin-like protein conjugating enzym... | 2.91e-03 | NA | NA | NA |
| GO:0140375 | immune receptor activity | 2.93e-03 | NA | NA | NA |
| GO:0042277 | peptide binding | 3.38e-03 | NA | NA | NA |
| GO:0005125 | cytokine activity | 3.40e-03 | NA | NA | NA |
| GO:0031681 | G-protein beta-subunit binding | 3.40e-03 | NA | NA | NA |
| GO:0019788 | NEDD8 transferase activity | 4.26e-03 | NA | NA | NA |
| GO:0004601 | peroxidase activity | 6.56e-03 | NA | NA | NA |
| GO:1903136 | cuprous ion binding | 6.84e-03 | NA | NA | NA |
| GO:0016684 | oxidoreductase activity, acting on perox... | 7.25e-03 | NA | NA | NA |
| GO:0004930 | G protein-coupled receptor activity | 7.76e-03 | NA | NA | NA |
| GO:0031386 | protein tag activity | 1.02e-02 | NA | NA | NA |
| GO:0141047 | molecular tag activity | 1.02e-02 | NA | NA | NA |
| GO:0003743 | translation initiation factor activity | 1.02e-02 | NA | NA | NA |
| GO:0016615 | malate dehydrogenase activity | 1.02e-02 | NA | NA | NA |
| GO:0061134 | peptidase regulator activity | 1.02e-02 | NA | NA | NA |
| GO:0048027 | mRNA 5'-UTR binding | 1.02e-02 | NA | NA | NA |
| GO:0004866 | endopeptidase inhibitor activity | 1.28e-02 | NA | NA | NA |
| GO:0098632 | cell-cell adhesion mediator activity | 1.35e-02 | NA | NA | NA |
| GO:0044183 | protein folding chaperone | 1.62e-02 | NA | NA | NA |
| GO:0061631 | ubiquitin conjugating enzyme activity | 1.78e-02 | NA | NA | NA |
| GO:0045296 | cadherin binding | 1.79e-02 | NA | NA | NA |
| GO:0086080 | protein binding involved in heterotypic ... | 1.98e-02 | NA | NA | NA |
| GO:0140678 | molecular function inhibitor activity | 1.98e-02 | NA | NA | NA |
| GO:0032977 | membrane insertase activity | 1.98e-02 | NA | NA | NA |
| GO:0070700 | BMP receptor binding | 1.98e-02 | NA | NA | NA |
| GO:0016494 | C-X-C chemokine receptor activity | 2.02e-02 | NA | NA | NA |
| GO:0048018 | receptor ligand activity | 2.30e-02 | NA | NA | NA |
| GO:0001609 | G protein-coupled adenosine receptor act... | 2.57e-02 | NA | NA | NA |
| GO:0030545 | signaling receptor regulator activity | 2.68e-02 | NA | NA | NA |
| GO:0008097 | 5S rRNA binding | 2.71e-02 | NA | NA | NA |
| GO:0046983 | protein dimerization activity | 2.77e-02 | NA | NA | NA |
| GO:0051087 | protein-folding chaperone binding | 2.77e-02 | NA | NA | NA |
| GO:0004954 | prostanoid receptor activity | 2.77e-02 | NA | NA | NA |
| GO:0004955 | prostaglandin receptor activity | 2.77e-02 | NA | NA | NA |
| GO:0030414 | peptidase inhibitor activity | 2.77e-02 | NA | NA | NA |
| GO:0009055 | electron transfer activity | 3.30e-02 | NA | NA | NA |
| GO:0008603 | cAMP-dependent protein kinase regulator ... | 3.83e-02 | NA | NA | NA |
| GO:0055102 | lipase inhibitor activity | 4.11e-02 | NA | NA | NA |
| GO:0008020 | G protein-coupled photoreceptor activity | 4.19e-02 | NA | NA | NA |
| GO:0016491 | oxidoreductase activity | 4.19e-02 | NA | NA | 4.73e-02 |
| GO:0030546 | signaling receptor activator activity | 4.58e-02 | NA | NA | NA |
| GO:0050839 | cell adhesion molecule binding | 4.93e-02 | NA | NA | NA |
| GO:0005524 | ATP binding | NA | 8.80e-19 | NA | NA |
| GO:0032559 | adenyl ribonucleotide binding | NA | 9.02e-19 | NA | NA |
| GO:0030554 | adenyl nucleotide binding | NA | 4.17e-18 | NA | NA |
| GO:0030695 | GTPase regulator activity | NA | 4.40e-14 | 4.34e-02 | NA |
| GO:0060589 | nucleoside-triphosphatase regulator acti... | NA | 4.40e-14 | 4.34e-02 | NA |
| GO:0005096 | GTPase activator activity | NA | 5.33e-14 | 1.68e-02 | NA |
| GO:0016773 | phosphotransferase activity, alcohol gro... | NA | 3.29e-13 | NA | NA |
| GO:0043167 | ion binding | NA | 3.59e-13 | NA | NA |
| GO:0016301 | kinase activity | NA | 1.37e-12 | NA | NA |
| GO:0016772 | transferase activity, transferring phosp... | NA | 1.82e-12 | NA | NA |
| GO:0140993 | histone modifying activity | NA | 5.46e-12 | NA | NA |
| GO:0004672 | protein kinase activity | NA | 1.68e-11 | NA | NA |
| GO:0036094 | small molecule binding | NA | 3.60e-11 | NA | NA |
| GO:0106310 | protein serine kinase activity | NA | 2.35e-09 | NA | NA |
| GO:0004674 | protein serine/threonine kinase activity | NA | 3.19e-09 | NA | NA |
| GO:0140030 | modification-dependent protein binding | NA | 1.02e-08 | NA | NA |
| GO:0043168 | anion binding | NA | 2.68e-08 | NA | NA |
| GO:0046872 | metal ion binding | NA | 3.10e-08 | NA | NA |
| GO:0043169 | cation binding | NA | 4.84e-08 | NA | NA |
| GO:0032553 | ribonucleotide binding | NA | 5.01e-08 | NA | NA |
| GO:0035639 | purine ribonucleoside triphosphate bindi... | NA | 5.80e-08 | NA | NA |
| GO:0032555 | purine ribonucleotide binding | NA | 8.08e-08 | NA | NA |
| GO:0017076 | purine nucleotide binding | NA | 1.56e-07 | NA | NA |
| GO:0042393 | histone binding | NA | 1.69e-07 | NA | NA |
| GO:0016887 | ATP hydrolysis activity | NA | 7.79e-07 | NA | NA |
| GO:1901363 | heterocyclic compound binding | NA | 8.76e-07 | NA | NA |
| GO:0004386 | helicase activity | NA | 1.42e-06 | NA | NA |
| GO:0000166 | nucleotide binding | NA | 1.42e-06 | NA | NA |
| GO:1901265 | nucleoside phosphate binding | NA | 1.67e-06 | NA | NA |
| GO:0003677 | DNA binding | NA | 2.70e-06 | 2.80e-02 | NA |
| GO:0003682 | chromatin binding | NA | 2.89e-06 | NA | NA |
| GO:0005085 | guanyl-nucleotide exchange factor activi... | NA | 3.99e-06 | NA | NA |
| GO:0140657 | ATP-dependent activity | NA | 5.69e-06 | NA | NA |
| GO:0035173 | histone kinase activity | NA | 5.89e-06 | NA | NA |
| GO:0097367 | carbohydrate derivative binding | NA | 6.36e-06 | NA | NA |
| GO:0044024 | histone H2AS1 kinase activity | NA | 9.90e-06 | NA | NA |
| GO:0140995 | histone H2A kinase activity | NA | 9.90e-06 | NA | NA |
| GO:0035091 | phosphatidylinositol binding | NA | 3.22e-05 | NA | NA |
| GO:0005543 | phospholipid binding | NA | 6.09e-05 | NA | NA |
| GO:0035064 | methylated histone binding | NA | 9.51e-05 | NA | NA |
| GO:0140034 | methylation-dependent protein binding | NA | 9.67e-05 | NA | NA |
| GO:0016740 | transferase activity | NA | 9.67e-05 | NA | NA |
| GO:0140947 | histone H3K9me2 methyltransferase activi... | NA | 1.02e-04 | NA | NA |
| GO:0140096 | catalytic activity, acting on a protein | NA | 1.49e-04 | NA | NA |
| GO:0031267 | small GTPase binding | NA | 1.93e-04 | 2.24e-02 | NA |
| GO:0140110 | transcription regulator activity | NA | 2.07e-04 | NA | NA |
| GO:0046976 | histone H3K27 methyltransferase activity | NA | 2.78e-04 | NA | NA |
| GO:0140938 | histone H3 methyltransferase activity | NA | 3.00e-04 | NA | NA |
| GO:0043565 | sequence-specific DNA binding | NA | 3.89e-04 | NA | NA |
| GO:0042054 | histone methyltransferase activity | NA | 4.29e-04 | NA | NA |
| GO:0140097 | catalytic activity, acting on DNA | NA | 4.29e-04 | NA | NA |
| GO:0051020 | GTPase binding | NA | 4.74e-04 | NA | NA |
| GO:0008289 | lipid binding | NA | 5.29e-04 | NA | NA |
| GO:0140033 | acetylation-dependent protein binding | NA | 7.95e-04 | NA | NA |
| GO:0140999 | histone H3K4 trimethyltransferase activi... | NA | 8.93e-04 | NA | NA |
| GO:0004713 | protein tyrosine kinase activity | NA | 1.08e-03 | NA | NA |
| GO:0070577 | lysine-acetylated histone binding | NA | 1.51e-03 | NA | NA |
| GO:0140939 | histone H4 methyltransferase activity | NA | 1.60e-03 | NA | NA |
| GO:0008094 | ATP-dependent activity, acting on DNA | NA | 1.67e-03 | NA | NA |
| GO:0004445 | inositol-polyphosphate 5-phosphatase act... | NA | 1.91e-03 | NA | NA |
| GO:0004683 | calcium/calmodulin-dependent protein kin... | NA | 1.91e-03 | NA | NA |
| GO:0009374 | biotin binding | NA | 1.93e-03 | NA | NA |
| GO:0008381 | mechanosensitive monoatomic ion channel ... | NA | 1.99e-03 | NA | NA |
| GO:0004016 | adenylate cyclase activity | NA | 2.37e-03 | NA | NA |
| GO:0003712 | transcription coregulator activity | NA | 2.40e-03 | NA | NA |
| GO:0140640 | catalytic activity, acting on a nucleic ... | NA | 2.45e-03 | NA | NA |
| GO:0003690 | double-stranded DNA binding | NA | 2.67e-03 | NA | NA |
| GO:0008047 | enzyme activator activity | NA | 2.67e-03 | 4.17e-02 | NA |
| GO:1990837 | sequence-specific double-stranded DNA bi... | NA | 3.64e-03 | NA | NA |
| GO:0030674 | protein-macromolecule adaptor activity | NA | 4.46e-03 | NA | NA |
| GO:0097159 | organic cyclic compound binding | NA | 4.88e-03 | NA | NA |
| GO:0016279 | protein-lysine N-methyltransferase activ... | NA | 6.19e-03 | NA | NA |
| GO:0140457 | protein demethylase activity | NA | 6.31e-03 | 2.83e-03 | NA |
| GO:0016849 | phosphorus-oxygen lyase activity | NA | 6.80e-03 | NA | NA |
| GO:0000976 | transcription cis-regulatory region bind... | NA | 7.84e-03 | NA | NA |
| GO:0008170 | N-methyltransferase activity | NA | 8.65e-03 | NA | NA |
| GO:0001067 | transcription regulatory region nucleic ... | NA | 8.66e-03 | NA | NA |
| GO:0016278 | lysine N-methyltransferase activity | NA | 1.03e-02 | NA | NA |
| GO:0032452 | histone demethylase activity | NA | 1.13e-02 | 2.98e-03 | NA |
| GO:0016741 | transferase activity, transferring one-c... | NA | 1.16e-02 | NA | NA |
| GO:0010484 | histone H3 acetyltransferase activity | NA | 1.20e-02 | NA | NA |
| GO:0060090 | molecular adaptor activity | NA | 1.35e-02 | NA | NA |
| GO:0008276 | protein methyltransferase activity | NA | 1.38e-02 | NA | NA |
| GO:0140658 | ATP-dependent chromatin remodeler activi... | NA | 1.40e-02 | NA | NA |
| GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphata... | NA | 1.51e-02 | NA | NA |
| GO:0046030 | inositol trisphosphate phosphatase activ... | NA | 1.54e-02 | NA | NA |
| GO:0071889 | 14-3-3 protein binding | NA | 1.61e-02 | NA | NA |
| GO:0003950 | NAD+-protein poly-ADP-ribosyltransferase... | NA | 1.75e-02 | NA | NA |
| GO:0008168 | methyltransferase activity | NA | 1.90e-02 | NA | NA |
| GO:0052659 | inositol-1,3,4,5-tetrakisphosphate 5-pho... | NA | 1.90e-02 | NA | NA |
| GO:0003824 | catalytic activity | NA | 1.97e-02 | NA | NA |
| GO:0031701 | angiotensin receptor binding | NA | 2.10e-02 | NA | NA |
| GO:0016706 | 2-oxoglutarate-dependent dioxygenase act... | NA | 2.14e-02 | NA | NA |
| GO:0003713 | transcription coactivator activity | NA | 2.14e-02 | NA | NA |
| GO:0015276 | ligand-gated monoatomic ion channel acti... | NA | 2.14e-02 | NA | NA |
| GO:0008186 | ATP-dependent activity, acting on RNA | NA | 2.15e-02 | NA | NA |
| GO:0005516 | calmodulin binding | NA | 2.15e-02 | NA | NA |
| GO:0048407 | platelet-derived growth factor binding | NA | 2.26e-02 | NA | NA |
| GO:0022834 | ligand-gated channel activity | NA | 2.26e-02 | NA | NA |
| GO:0001409 | guanine nucleotide transmembrane transpo... | NA | 2.28e-02 | NA | NA |
| GO:0022836 | gated channel activity | NA | 2.28e-02 | NA | NA |
| GO:0141052 | histone H3 demethylase activity | NA | 2.33e-02 | 1.82e-03 | NA |
| GO:0003678 | DNA helicase activity | NA | 2.68e-02 | NA | NA |
| GO:0036408 | histone H3K14 acetyltransferase activity | NA | 2.75e-02 | NA | NA |
| GO:0141039 | phosphatidylinositol 3-kinase inhibitor ... | NA | 2.89e-02 | NA | NA |
| GO:0043139 | 5'-3' DNA helicase activity | NA | 3.10e-02 | NA | NA |
| GO:0008349 | MAP kinase kinase kinase kinase activity | NA | 3.10e-02 | NA | NA |
| GO:0016273 | arginine N-methyltransferase activity | NA | 3.10e-02 | NA | NA |
| GO:0016274 | protein-arginine N-methyltransferase act... | NA | 3.10e-02 | NA | NA |
| GO:0008017 | microtubule binding | NA | 3.10e-02 | 3.24e-03 | NA |
| GO:0140566 | histone reader activity | NA | 3.11e-02 | NA | NA |
| GO:0099094 | ligand-gated monoatomic cation channel a... | NA | 3.41e-02 | NA | NA |
| GO:0003724 | RNA helicase activity | NA | 3.41e-02 | NA | NA |
| GO:0009975 | cyclase activity | NA | 3.49e-02 | NA | NA |
| GO:0003774 | cytoskeletal motor activity | NA | 3.56e-02 | NA | NA |
| GO:0008757 | S-adenosylmethionine-dependent methyltra... | NA | 3.60e-02 | NA | NA |
| GO:1901981 | phosphatidylinositol phosphate binding | NA | 3.98e-02 | NA | NA |
| GO:0042800 | histone H3K4 methyltransferase activity | NA | 4.23e-02 | NA | NA |
| GO:0033558 | protein lysine deacetylase activity | NA | 4.89e-02 | NA | NA |
| GO:0004712 | protein serine/threonine/tyrosine kinase... | NA | 4.89e-02 | NA | NA |
| GO:0000149 | SNARE binding | NA | NA | 2.83e-03 | NA |
| GO:0015631 | tubulin binding | NA | NA | 2.83e-03 | NA |
| GO:0032454 | histone H3K9 demethylase activity | NA | NA | 2.83e-03 | NA |
| GO:0005488 | binding | NA | NA | 9.42e-03 | NA |
| GO:0046914 | transition metal ion binding | NA | NA | 1.56e-02 | NA |
| GO:0008270 | zinc ion binding | NA | NA | 1.68e-02 | NA |
| GO:0019783 | ubiquitin-like protein peptidase activit... | NA | NA | 1.68e-02 | NA |
| GO:0032451 | demethylase activity | NA | NA | 1.93e-02 | NA |
| GO:0043394 | proteoglycan binding | NA | NA | 2.03e-02 | NA |
| GO:0004843 | cysteine-type deubiquitinase activity | NA | NA | 2.11e-02 | NA |
| GO:0051864 | histone H3K36 demethylase activity | NA | NA | 3.53e-02 | NA |
| GO:0101005 | deubiquitinase activity | NA | NA | 3.61e-02 | NA |
| GO:0035242 | protein-arginine omega-N asymmetric meth... | NA | NA | NA | 3.13e-02 |
| GO:0001054 | RNA polymerase I activity | NA | NA | NA | 3.37e-02 |
| GO.ID | Term | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|---|
| GO:0004239 | initiator methionyl aminopeptidase activ... | 3.45e-02 | NA | NA |
| GO:0030554 | adenyl nucleotide binding | NA | 1.17e-05 | NA |
| GO:0005524 | ATP binding | NA | 1.47e-05 | NA |
| GO:0032559 | adenyl ribonucleotide binding | NA | 1.47e-05 | NA |
| GO:0016772 | transferase activity, transferring phosp... | NA | 5.29e-04 | NA |
| GO:0016773 | phosphotransferase activity, alcohol gro... | NA | 1.44e-03 | NA |
| GO:0016301 | kinase activity | NA | 1.59e-03 | NA |
| GO:0140993 | histone modifying activity | NA | 5.73e-03 | NA |
| GO:1901363 | heterocyclic compound binding | NA | 9.70e-03 | NA |
| GO:0043168 | anion binding | NA | 1.41e-02 | NA |
| GO:1901265 | nucleoside phosphate binding | NA | 1.41e-02 | NA |
| GO:0000166 | nucleotide binding | NA | 1.41e-02 | NA |
| GO:0043167 | ion binding | NA | 1.45e-02 | NA |
| GO:0017076 | purine nucleotide binding | NA | 1.58e-02 | NA |
| GO:0004672 | protein kinase activity | NA | 1.58e-02 | NA |
| GO:0070061 | fructose binding | NA | 1.58e-02 | NA |
| GO:0035639 | purine ribonucleoside triphosphate bindi... | NA | 1.58e-02 | NA |
| GO:0036094 | small molecule binding | NA | 1.58e-02 | NA |
| GO:0032553 | ribonucleotide binding | NA | 1.58e-02 | NA |
| GO:0042054 | histone methyltransferase activity | NA | 1.58e-02 | NA |
| GO:0051015 | actin filament binding | NA | 1.58e-02 | NA |
| GO:0016741 | transferase activity, transferring one-c... | NA | 1.58e-02 | NA |
| GO:0016627 | oxidoreductase activity, acting on the C... | NA | 1.58e-02 | NA |
| GO:0008168 | methyltransferase activity | NA | 1.58e-02 | NA |
| GO:0140640 | catalytic activity, acting on a nucleic ... | NA | 1.62e-02 | NA |
| GO:0032555 | purine ribonucleotide binding | NA | 1.81e-02 | NA |
| GO:0004674 | protein serine/threonine kinase activity | NA | 2.11e-02 | NA |
| GO:0019213 | deacetylase activity | NA | 2.20e-02 | NA |
| GO:0140939 | histone H4 methyltransferase activity | NA | 2.20e-02 | NA |
| GO:0008757 | S-adenosylmethionine-dependent methyltra... | NA | 2.20e-02 | NA |
| GO:0106310 | protein serine kinase activity | NA | 2.20e-02 | NA |
| GO:0030695 | GTPase regulator activity | NA | 2.20e-02 | NA |
| GO:0060589 | nucleoside-triphosphatase regulator acti... | NA | 2.20e-02 | NA |
| GO:0004386 | helicase activity | NA | 2.20e-02 | NA |
| GO:0003824 | catalytic activity | NA | 2.42e-02 | NA |
| GO:0140030 | modification-dependent protein binding | NA | 2.64e-02 | NA |
| GO:0097367 | carbohydrate derivative binding | NA | 2.64e-02 | NA |
| GO:0008276 | protein methyltransferase activity | NA | 3.33e-02 | NA |
| GO:0035242 | protein-arginine omega-N asymmetric meth... | NA | 3.33e-02 | NA |
| GO:0016740 | transferase activity | NA | 3.80e-02 | NA |
| GO:0008381 | mechanosensitive monoatomic ion channel ... | NA | 3.80e-02 | NA |
| GO:0008170 | N-methyltransferase activity | NA | 4.66e-02 | NA |
| GO:0003735 | structural constituent of ribosome | NA | NA | 1.61e-03 |
| GO:0030527 | structural constituent of chromatin | NA | NA | 1.61e-03 |
| GO:0046982 | protein heterodimerization activity | NA | NA | 2.59e-02 |
| GO.ID | Term | positive.PC.1 | negative.PC.1 | positive.PC.2 | negative.PC.2 |
|---|---|---|---|---|---|
| GO:0005125 | cytokine activity | 3.56e-12 | NA | NA | NA |
| GO:0005126 | cytokine receptor binding | 6.22e-12 | NA | NA | NA |
| GO:0023026 | MHC class II protein complex binding | 3.00e-11 | NA | NA | NA |
| GO:0005518 | collagen binding | 2.95e-10 | NA | NA | NA |
| GO:0019207 | kinase regulator activity | 2.95e-10 | NA | NA | NA |
| GO:0005525 | GTP binding | 1.30e-09 | NA | NA | NA |
| GO:0019001 | guanyl nucleotide binding | 1.30e-09 | NA | NA | NA |
| GO:0032561 | guanyl ribonucleotide binding | 1.30e-09 | NA | NA | NA |
| GO:0003823 | antigen binding | 2.22e-09 | NA | NA | NA |
| GO:0001664 | G protein-coupled receptor binding | 2.78e-07 | NA | NA | NA |
| GO:0008013 | beta-catenin binding | 6.93e-05 | NA | NA | NA |
| GO:0016491 | oxidoreductase activity | 2.80e-02 | NA | NA | NA |
| GO:0046914 | transition metal ion binding | 2.80e-02 | NA | NA | NA |
| GO.ID | Term | Cluster 1 | Cluster 2 | Cluster 3 |
|---|---|---|---|---|
| GO:0008013 | beta-catenin binding | 6.14e-03 | NA | NA |
| GO:0140657 | ATP-dependent activity | 4.51e-02 | NA | NA |
| GO:0022804 | active transmembrane transporter activit... | 4.51e-02 | NA | NA |
| final_main_params | |
|---|---|
| model_organism | Human |
| annot_table | NULL |
| input_gene_id | ENSEMBL |
| custom | NULL |
| enrich_dbs | c("Reactome", "KEGG", "BP", "CC", "MF") |
| kegg_data_file | /Users/marmtnez/Desktop/Master_Bioinfo/TFM/installed_software/ExpHunterSuite/inst/scripts/../../inst/kegg_data_files/hsa_KEGG.rds |
| enrich_methods | ORA |
| annotation_source | orgdb |
| pthreshold | 0.1 |
| qthreshold | 0.2 |
| cores | 1 |
| task_size | 10 |
| output_files | /Users/marmtnez/Desktop/Master_Bioinfo/TFM/Results/functional/ctrl_vs_gtdup_fe |
| fc_colname | mean_logFCs |
| universe | NULL |
| clean_parentals | FALSE |
| simplify | FALSE |
| top_categories | 50 |
| sim_thr | NULL |
| summary_common_name | ancestor |
| clusters_flag | TRUE |